通过纳米医学增强联合免疫治疗和放射治疗。
Enhancing Combined Immunotherapy and Radiotherapy through Nanomedicine.
机构信息
Laboratory of Nano- and Translational Medicine, Lineberger Comprehensive Cancer Center, Carolina Center for Cancer Nanotechnology Excellence, Carolina Institute of Nanomedicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
Department of Radiation Oncology, Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States.
出版信息
Bioconjug Chem. 2020 Dec 16;31(12):2668-2678. doi: 10.1021/acs.bioconjchem.0c00520. Epub 2020 Nov 30.
Radiotherapy and immunotherapy are two key treatments for cancer. There is growing evidence that they are also synergistic, and combination treatments are being studied extensively in the clinical setting. In addition, there is emerging evidence that nanotechnology-enabled therapeutics can potentiate both radiotherapy and immunotherapy, in turn improving both treatments. This is an exciting new area of interdisciplinary science and has significant potential for major clinical impact. Some of the approaches in this area have already reached the clinical stage. In this review, we will discuss recent advances in the interface between radiotherapy, immunotherapy, and nanomedicine. We plan to review the many approaches to combine these three fields for cancer treatment.
放疗和免疫疗法是癌症的两种主要治疗方法。越来越多的证据表明，它们也是协同作用的，联合治疗正在临床中广泛研究。此外，有新的证据表明，纳米技术使能的治疗方法可以增强放疗和免疫疗法的效果，从而改善这两种治疗方法。这是一个令人兴奋的新的跨学科科学领域，具有重大的临床影响潜力。该领域的一些方法已经进入临床阶段。在这篇综述中，我们将讨论放疗、免疫疗法和纳米医学之间的界面的最新进展。我们计划回顾将这三个领域结合起来治疗癌症的多种方法。
Zotero 插件