Center for Biomedical Engineering, University of New Mexico, Albuquerque 87131-0001, New Mexico, United States.
Biomedical Engineering Graduate Program, University of New Mexico, Albuquerque 87131-0001, New Mexico, United States.
ACS Appl Mater Interfaces. 2020 Dec 16;12(50):55688-55695. doi: 10.1021/acsami.0c17445. Epub 2020 Dec 2.
In the present study, we examined the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by synthetic conjugated polymers and oligomers developed in our laboratories as antimicrobials for bacteria, fungi, and nonenveloped viruses. The results show highly effective light-induced inactivation with several of these oligomers and polymers including irradiation with near-UV and visible light. In the best case, one oligomer induced a 5-log reduction in pfu/mL within 10 min. In general, the oligomers are more active than the polymers; however, the polymers are active with longer wavelength visible irradiation. Although not studied quantitatively, the results show that in the presence of the agents at concentrations similar to those used in the light studies, there is essentially no dark inactivation of the virus. Because three of the five materials/compounds examined are quaternary ammonium derivatives, this study indicates that conventional quaternary ammonium antimicrobials may not be active against SARS-CoV-2. Our results suggest several applications involving the incorporation of these materials in wipes, sprays, masks, and clothing and other personal protection equipment that can be useful in preventing infections and the spreading of this deadly virus and future outbreaks from similar viruses.
在本研究中，我们研究了合成共轭聚合物和低聚物对严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）的灭活作用，这些聚合物和低聚物是我们实验室开发的用于细菌、真菌和非包膜病毒的抗菌剂。结果表明，这些低聚物和聚合物中的几种具有高效的光诱导灭活作用，包括近紫外和可见光照射。在最佳情况下，一种低聚物在 10 分钟内将 pfu/mL 降低了 5 个对数级。一般来说，低聚物比聚合物更有效；然而，聚合物在更长波长的可见光照射下具有活性。尽管没有进行定量研究，但结果表明，在与光研究中使用的浓度相似的试剂存在下，病毒基本上没有暗失活。由于所检查的五种材料/化合物中有三种是季铵盐衍生物，因此本研究表明，传统的季铵盐抗菌剂可能对 SARS-CoV-2 无效。我们的结果表明，这些材料可以应用于擦拭布、喷雾剂、口罩、衣物和其他个人防护设备中，以防止这种致命病毒的感染和传播，以及未来类似病毒的爆发。
