Center for Global Health Practice and Impact, Georgetown University, Washington, DC, USA.
Global Health Division, The Bill & Melinda Gates Foundation, Seattle, WA, USA.
Lancet HIV. 2021 Jan;8(1):e51-e58. doi: 10.1016/S2352-3018(20)30232-0. Epub 2020 Nov 30.
In light of the increasing global burden of new HIV infections, growing financial requirements, and shifting funding landscape, the global health community must accelerate the development and delivery of an HIV cure to complement existing prevention modalities. An effective curative intervention could prevent new infections, overcome the limitations of antiretroviral treatment, combat stigma and discrimination, and provide a sustainable financial solution for pandemic control. We propose steps to plan for an HIV cure now, including defining a target product profile and establishing the HIV Cure Africa Acceleration Partnership (HCAAP), a multidisciplinary public-private partnership that will catalyse and promote HIV cure research through diverse stakeholder engagement. HCAAP will convene stakeholders, including people living with HIV, at an early stage to accelerate the design, social acceptability, and rapid adoption of HIV-cure products.
鉴于新的 HIV 感染全球负担不断增加、资金需求不断增长以及资金格局不断变化，全球卫生界必须加快开发和提供艾滋病毒治愈方法，以补充现有的预防模式。有效的治愈性干预措施可以预防新的感染，克服抗逆转录病毒治疗的局限性，消除耻辱和歧视，并为控制大流行提供可持续的财政解决方案。我们提出了现在就为艾滋病毒治愈方法做规划的步骤，包括定义目标产品概况和建立非洲艾滋病毒治愈加速伙伴关系（HCAAP），这是一个多学科的公私伙伴关系，将通过不同利益攸关方的参与来促进和推动艾滋病毒治愈研究。HCAAP 将召集利益攸关方，包括艾滋病毒感染者，尽早加速艾滋病毒治愈产品的设计、社会可接受性和快速采用。
