Song Yanlin, He Min, Zhang Jing, Xu Jianguo
Department of Neurosurgery and National Clinical Research Center for Geriatrics.
Department of Biotherapy and Cancer Center.
Medicine (Baltimore). 2020 Dec 4;99(49):e23163. doi: 10.1097/MD.0000000000023163.
MicroRNA 221 has been found to be a good marker for several cancers. Some studies also focused on the relationship between microRNA 221 and glioma. However, the results are controversial. We aimed to systematically evaluate the prognostic role of microRNA 221 in glioma through performing a meta-analysis.
The articles which were included in our study were searched on the Web of Science, EMBASE, PubMed, Cochrane Library and China National Knowledge Infrastructure. The basic characteristics and relevant data were extracted. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled to evaluate the prognostic role of microRNA 221 in glioma.
Eight studies with 1069 patients were included. We systematically evaluated the role of microRNA 221 for overall survival (OS) and disease free survival (DFS) in glioma patients (HR for OS = 1.66, 95% CI, 1.34-2.04; HR for DFS = 1.14, 95% CI, 1.02-1.26). Subgroup analyses were performed according to the nation of the studies, the origin of the samples, the stage of the tumors, the cut-off value, and the method for detecting the microRNA 221. No significant publication bias was found (P = .133).
In conclusion, high expression of microRNA 221 was related to poor prognosis of glioma. These findings may assist future exploration on microRNA 221 and help predict the prognosis of glioma. However, due to the significant heterogeneity of these studies, more studies are warranted.
微小RNA 221已被发现是多种癌症的良好标志物。一些研究也聚焦于微小RNA 221与胶质瘤之间的关系。然而，结果存在争议。我们旨在通过进行一项荟萃分析来系统评估微小RNA 221在胶质瘤中的预后作用。
在科学网、EMBASE、PubMed、Cochrane图书馆和中国知网中检索纳入我们研究的文章。提取基本特征和相关数据。汇总具有95%置信区间（CI）的风险比（HR），以评估微小RNA 221在胶质瘤中的预后作用。
纳入了八项研究，共1069例患者。我们系统评估了微小RNA 221对胶质瘤患者总生存期（OS）和无病生存期（DFS）的作用（OS的HR = 1.66，95% CI为1.34 - 2.04；DFS的HR = 1.14，95% CI为1.02 - 1.26）。根据研究国家、样本来源、肿瘤分期、截断值以及检测微小RNA 221的方法进行了亚组分析。未发现显著的发表偏倚（P = 0.133）。
总之，微小RNA 221的高表达与胶质瘤的不良预后相关。这些发现可能有助于未来对微小RNA 221的探索，并有助于预测胶质瘤的预后。然而，由于这些研究存在显著的异质性，需要更多的研究。
