Amini Shahideh, Ghasemi Arezou, Solduzian Mohammad, Rahimi Besharat, Heidari Kazem, Hadjibabaie Molouk, Kargar Mona
Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Curr Ther Res Clin Exp. 2020 Oct 20;93:100608. doi: 10.1016/j.curtheres.2020.100608. eCollection 2020.
Inhalers are the mainstay of treatment for patients suffering from chronic obstructive pulmonary disease. However, incorrect inhaler technique is a considerable challenge.
We aimed to evaluate inhaler technique and its association with quality of life in a sample of patients with chronic obstructive pulmonary disease.
This cross-sectional study included patients with confirmed chronic obstructive pulmonary disease who were prescribed at least 1 inhaler medication on a regular basis. Patients were recruited from the outpatient pulmonary clinic of a hospital in Tehran. Inhaler technique was assessed according to a validated checklist. Patients' quality of life was evaluated using Chronic Obstructive Pulmonary Disease Assessment Test.
One hundred seventy-five patients with mean (SD) age of 59.0 (10.1) years were included. Patients' devices were 192 (62.3%) pressurized metered-dose inhalers (including pressurized metered-dose inhalers plus spacer) and 116 (37.7%) dry powder inhalers. Unfortunately, only 2.86% of patients used their inhalers completely correct. The highest rate of errors was committed by patients who used metered-dose inhalers plus spacer. Patients with a higher educational degree had significantly lower rate of errors on average ( = 0.001). The most frequent errors made by patients using pressurized metered-dose inhalers or Turbuhaler was priming the inhaler before the first administration in 90.6% and 78.3% of patients, respectively. Chronic Obstructive Pulmonary Disease Assessment Test scores in patients using different inhaler devices were not significantly different. However, in patients with lower quality of life, significantly more patients had poor inhaler technique ( = 0.0001).
There is still considerable need for interventions to optimize inhaler technique. We also noted that appropriate inhaler technique is associated with better quality of life. (. 2020; 81:XXX-XXX).
吸入器是慢性阻塞性肺疾病患者治疗的主要手段。然而，不正确的吸入器使用技术是一个相当大的挑战。
我们旨在评估慢性阻塞性肺疾病患者样本中的吸入器使用技术及其与生活质量的关联。
这项横断面研究纳入了确诊为慢性阻塞性肺疾病且定期使用至少一种吸入器药物的患者。患者从德黑兰一家医院的门诊肺部诊所招募。根据一份经过验证的检查表评估吸入器使用技术。使用慢性阻塞性肺疾病评估测试评估患者的生活质量。
纳入了175例患者，平均（标准差）年龄为59.0（10.1）岁。患者使用的装置为192个（62.3%）压力定量吸入器（包括压力定量吸入器加储雾罐）和116个（37.7%）干粉吸入器。遗憾的是，只有2.86%的患者完全正确地使用了他们的吸入器。使用定量吸入器加储雾罐的患者出错率最高。平均而言，受教育程度较高的患者出错率显著较低（P = 0.001）。使用压力定量吸入器或都保的患者最常见的错误分别是在首次给药前对吸入器进行初始化，在患者中占比分别为90.6%和78.3%。使用不同吸入器装置的患者的慢性阻塞性肺疾病评估测试得分无显著差异。然而，在生活质量较低的患者中，吸入器使用技术差的患者明显更多（P = 0.0001）。
仍非常需要采取干预措施来优化吸入器使用技术。我们还注意到，正确的吸入器使用技术与更好的生活质量相关。（. 2020；81：XXX - XXX）
