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在大鼠中风模型中，脑缺血急性期静脉注射辅酶Q10可通过减少脑坏死并在4天内限制其增加来降低死亡率。

Intravenous Administration of Coenzyme Q10 in Acute Period of Cerebral Ischemia Decreases Mortality by Reducing Brain Necrosis and Limiting Its Increase within 4 Days in Rat Stroke Model.

作者信息

Olga Nikolaevna Obolenskaia, Evgeniya Aronovna Gorodetskaya, Elena Igorevna Kalenikova, Margarita Alekseevna Belousova, Mikhail Vladimirovich Gulyaev, Valery Gennadievich Makarov, Yury Andreevich Pirogov, Oleg Stephanovich Medvedev

机构信息

Faculty of Medicine, Lomonosov Moscow State University, 119991 Moscow, Russia.

Research and Production Association «House of Pharmacy», 188663 Saint Petersburg, Russia.

出版信息

Antioxidants (Basel). 2020 Dec 7;9(12):1240. doi: 10.3390/antiox9121240.

DOI:10.3390/antiox9121240
PMID:33297323
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7762283/
Abstract

Oxidative stress plays a key role in the pathogenesis of ischemic stroke. Coenzyme Q10 has a multi-targeting effect and may protect the brain against ischemic damage. The aim of our study was to evaluate the neuroprotective potential of ubiquinol by its intravenous administration. The study was performed on rats; a stroke was modeled by occlusion of the middle cerebral artery. On days 1 and 4 after ischemia, the neurological deficit and volume of the brain lesion were determined by MRI and TTC staining. Intravenous administration of coenzyme Q10 led to a decrease in rat mortality rate, improvement in neurological status, and decrease in the brain necrosis area in acute and delayed period after cerebral ischemia. A single intravenous administration of ubiquinol led to a limitation of the size of the brain damage for at least four days after ischemia. Thus, intravenous administration of coenzyme Q10 has a persistent neuroprotective potential. This finding suggests a possible therapeutic role of ubiquinol in acute ischemic conditions.

摘要

氧化应激在缺血性中风的发病机制中起关键作用。辅酶Q10具有多靶点作用，可能保护大脑免受缺血损伤。我们研究的目的是评估通过静脉注射泛醇的神经保护潜力。该研究在大鼠身上进行；通过大脑中动脉闭塞建立中风模型。在缺血后第1天和第4天，通过MRI和TTC染色确定神经功能缺损和脑损伤体积。静脉注射辅酶Q10可降低大鼠死亡率，改善神经功能状态，并减少脑缺血急性期和延迟期的脑坏死面积。单次静脉注射泛醇可在缺血后至少四天限制脑损伤的大小。因此，静脉注射辅酶Q10具有持久的神经保护潜力。这一发现表明泛醇在急性缺血性疾病中可能具有治疗作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/72145cfe19ac/antioxidants-09-01240-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/c929b0d72c47/antioxidants-09-01240-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/72145cfe19ac/antioxidants-09-01240-g011.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/b172ce37671a/antioxidants-09-01240-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/cf50b156e5b5/antioxidants-09-01240-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/b612e2cfc189/antioxidants-09-01240-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/c929b0d72c47/antioxidants-09-01240-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a872/7762283/72145cfe19ac/antioxidants-09-01240-g011.jpg

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