School of Mathematical Sciences, Peking University, Beijing, 100871, China.
Center for Statistical Sciences, Peking University, Beijing, 100871, China.
Sci Rep. 2020 Dec 9;10(1):21522. doi: 10.1038/s41598-020-76630-0.
The current outbreak of coronavirus disease 2019 (COVID-19) has become a global crisis due to its quick and wide spread over the world. A good understanding of the dynamic of the disease would greatly enhance the control and prevention of COVID19. However, to the best of our knowledge, the unique features of the outbreak have limited the applications of all existing dynamic models. In this paper, a novel stochastic model was proposed aiming to account for the unique transmission dynamics of COVID-19 and capture the effects of intervention measures implemented in Mainland China. We found that: (1) instead of aberration, there was a remarkable amount of asymptomatic virus carriers, (2) a virus carrier with symptoms was approximately twice more likely to pass the disease to others than that of an asymptomatic virus carrier, (3) the transmission rate reduced significantly since the implementation of control measures in Mainland China, and (4) it was expected that the epidemic outbreak would be contained by early March in the selected provinces and cities in China.
当前 2019 年冠状病毒病(COVID-19)的爆发因其在世界范围内迅速而广泛的传播已成为一场全球危机。对疾病动态的良好理解将极大地增强对 COVID19 的控制和预防。然而,据我们所知,疫情的独特特征限制了所有现有动力学模型的应用。在本文中,我们提出了一种新的随机模型,旨在考虑 COVID-19 的独特传播动态,并捕捉在中国大陆实施的干预措施的效果。我们发现:(1)存在大量无症状病毒携带者,而不是异常情况,(2)有症状的病毒携带者将疾病传染给他人的可能性大约是无症状病毒携带者的两倍,(3)自中国大陆实施控制措施以来,传播率显著降低,(4)预计疫情将在选定的中国省份和城市于 3 月初得到控制。