Department of Pharmacy, Xuzhou Maternity and Child Health Care Hospital, Xuzhou 221000, China.
Reproductive Medical Center, Jinling Hospital Affiliated to The Medical School of Nanjing University, Nanjing 210002, China.
Biomed Res Int. 2020 Nov 24;2020:8838676. doi: 10.1155/2020/8838676. eCollection 2020.
Obesity is directly associated with the risk of cancer in different organs, including breast, colon, and kidney. However, adipocytes could be utilized to control progression for some types of cancer, such as leukemia and breast cancer. To explore the potential correlation between adipocytes and cancer, the combined effect of expression levels of obesity-related genes and clinical factors (i.e., gender, race, menopausal status, history of smoking, tumor grade, body mass index (BMI), and history of drinking) on cancer survival rate was systemically studied. The expression levels of obesity-related genes in cancer tissues and normal tissues were downloaded from The Cancer Genome Atlas (TCGA). Kaplan-Meier curves were plotted using R programming language. The log-rank test was applied to explore the correlation between different clinical subgroups. The overexpression of the nine obesity-related genes (, , , , , , , , and ) may associate with tumor-promoting factors in some organs (head and neck, gastrointestinal tract, liver, and gallbladder). Underexpressed , , , and genes prevented the progression and metastasis of kidney cancer. The combined effect of clinical factors and the expression levels of obesity-related genes on patients' survival was found to be significant. Our outcomes suggested that the alternations of DNA methylation patterns could result in the changes of expression levels of obesity-related genes, playing a critical role in tumor progression. The results of the current study may be utilized to supplement precision and personalized medicine, as well as provide novel insights for the development of treatment approaches for cancer.
肥胖与不同器官的癌症风险直接相关，包括乳腺癌、结肠癌和肾癌。然而，脂肪细胞可以被用来控制某些类型癌症的进展，如白血病和乳腺癌。为了探索脂肪细胞与癌症之间的潜在相关性，本研究系统地研究了肥胖相关基因的表达水平与临床因素（即性别、种族、绝经状态、吸烟史、肿瘤分级、体重指数（BMI）和饮酒史）的综合效应与癌症存活率之间的关系。从癌症基因组图谱（TCGA）下载癌症组织和正常组织中肥胖相关基因的表达水平。使用 R 编程语言绘制 Kaplan-Meier 曲线。对数秩检验用于探索不同临床亚组之间的相关性。九个肥胖相关基因（、、、、、、、和）的过表达可能与某些器官（头颈部、胃肠道、肝脏和胆囊）中的肿瘤促进因素有关。表达下调的、、、和基因可阻止肾癌的进展和转移。临床因素和肥胖相关基因表达水平对患者生存的综合影响被发现具有统计学意义。我们的研究结果表明，DNA 甲基化模式的改变可能导致肥胖相关基因表达水平的变化，在肿瘤进展中发挥关键作用。本研究的结果可用于补充精准医学和个性化医学，并为癌症治疗方法的发展提供新的见解。
