Dept of Neuroscience, Uppsala University, Uppsala, Sweden.
Clinical Physiology, Dept of Medical Sciences, Uppsala University, Uppsala, Sweden.
Eur Respir J. 2021 Jun 4;57(6). doi: 10.1183/13993003.03344-2020. Print 2021 Jun.
We investigated the prevalence of chronic cough and its association with work ability and sick leave in the general population.Data were analysed from the Respiratory Health In Northern Europe (RHINE) III cohort (n=13 500), of which 11 252 participants had also participated in RHINE II 10 years earlier, a multicentre study in Northern Europe. Participants answered a questionnaire on chronic cough, employment factors, smoking and respiratory comorbidities.Nonproductive chronic cough was found in 7% and productive chronic cough in 9% of the participants. Participants with nonproductive cough were more often female and participants with productive cough were more often smokers and had a higher body mass index (BMI) than those without cough. Participants with chronic cough more often reported >7 days of sick leave in the preceding year than those without cough ("nonproductive cough" 21% and "productive cough" 24%; p<0.001 for comparisons with "no cough" 13%). This pattern was consistent after adjusting for age, sex, BMI, education level, smoking status and comorbidities. Participants with chronic cough at baseline reported lower work ability and more often had >7 days of sick leave at follow-up than those without cough. These associations remained significant after adjusting for cough at follow-up and other confounding factors.Chronic cough was found in around one in six participants and was associated with more sick leave. Chronic cough 10 years earlier was associated with lower work ability and sick leave at follow-up. These associations were not explained by studied comorbidities. This indication of negative effects on employment from chronic cough needs to be recognised.
我们调查了普通人群中慢性咳嗽的患病率及其与工作能力和病假的关系。该数据来自北欧呼吸系统健康研究（RHINE）III 队列（n=13500），其中 11252 名参与者也参加了 10 年前的 RHINE II 多中心研究。参与者回答了一份关于慢性咳嗽、就业因素、吸烟和呼吸合并症的问卷。无痰慢性咳嗽在 7%的参与者中发现，有痰慢性咳嗽在 9%的参与者中发现。无痰咳嗽的参与者更多为女性，有痰咳嗽的参与者更多为吸烟者，且体重指数（BMI）高于无咳嗽的参与者。与无咳嗽的参与者相比，有慢性咳嗽的参与者在前一年有更多的病假天数（“无痰咳嗽”为 21%，“有痰咳嗽”为 24%；与“无咳嗽”相比，p<0.001）。调整年龄、性别、BMI、教育水平、吸烟状况和合并症后，这种模式仍然存在。在基线时有慢性咳嗽的参与者报告工作能力较低，在随访时有更多的病假天数（>7 天），与无咳嗽的参与者相比。调整随访时的咳嗽和其他混杂因素后，这些关联仍然显著。大约六分之一的参与者有慢性咳嗽，与更多的病假有关。10 年前的慢性咳嗽与随访时的工作能力较低和病假天数较多有关。这些关联不能用研究中的合并症来解释。慢性咳嗽对就业的负面影响需要得到重视。
