Qin Qing, Liu Ya-Jiao, Shan Bo-Nan, Che Yan-Qiu, Han Chun-Xiao, Qin Ying-Mei, Wang Jiang
Tianjin Key Laboratory of Information Sensing & Intelligent Control, School of Automation and Electrical Engineering, Tianjin University of Technology and Education, Tianjin, China.
School of Electrical and Information Engineering, Tianjin University, Tianjin, China.
Front Comput Neurosci. 2020 Nov 16;14:532193. doi: 10.3389/fncom.2020.532193. eCollection 2020.
Acupuncturing the ST36 acupoint can evoke the response of the sensory nervous system, which is translated into output electrical signals in the spinal dorsal root. Neural response activities, especially synchronous spike events, evoked by different acupuncture manipulations have remarkable differences. In order to identify these network collaborative activities, we analyze the underlying spike correlation in the synchronous spike event. In this paper, we adopt a log-linear model to describe network response activities evoked by different acupuncture manipulations. Then the state-space model and Bayesian theory are used to estimate network spike correlations. Two sets of simulation data are used to test the effectiveness of the estimation algorithm and the model goodness-of-fit. In addition, simulation data are also used to analyze the relationship between spike correlations and synchronous spike events. Finally, we use this method to identify network spike correlations evoked by four different acupuncture manipulations. Results show that reinforcing manipulations (twirling reinforcing and lifting-thrusting reinforcing) can evoke the third-order spike correlation but reducing manipulations (twirling reducing and lifting-thrusting reducing) does not. This is the main reason why synchronous spikes evoked by reinforcing manipulations are more abundant than reducing manipulations.
针刺足三里穴可诱发感觉神经系统的反应，该反应在脊髓背根中转化为输出电信号。不同针刺手法诱发的神经反应活动，尤其是同步放电事件，存在显著差异。为了识别这些网络协同活动，我们分析了同步放电事件中潜在的放电相关性。本文采用对数线性模型来描述不同针刺手法诱发的网络反应活动。然后利用状态空间模型和贝叶斯理论估计网络放电相关性。使用两组模拟数据来检验估计算法的有效性和模型的拟合优度。此外，模拟数据还用于分析放电相关性与同步放电事件之间的关系。最后，我们用该方法识别四种不同针刺手法诱发的网络放电相关性。结果表明，补法（捻转补法和提插补法）可诱发三阶放电相关性，而泻法（捻转泻法和提插泻法）则不能。这是补法诱发的同步放电比泻法更丰富的主要原因。
