Andrade Joana M, Domínguez-Martín Eva María, Nicolai Marisa, Faustino Célia, Rodrigues Luís Monteiro, Rijo Patrícia
Research Center for Biosciences and Health Technologies (CBIOS), Universidade Lusófona de Humanidades e Tecnologias, Lisboa, Portugal.
Department of Biomedical Sciences, Faculty of Pharmacy, University of Alcalá, Madrid, Spain.
J Enzyme Inhib Med Chem. 2021 Dec;36(1):257-269. doi: 10.1080/14756366.2020.1862099.
A series of spp. plant extracts (aqueous, acetonic, methanolic and ethyl acetic) obtained from eight different species, and previously isolated compounds (ranging from polyphenols, diterpenes and triterpenes), were assayed for inhibition of the skin-related enzymes tyrosinase, collagenase and elastase, and for studying their antioxidant properties. The ethyl acetic extracts of and registered the highest antioxidant activity, whereas acetonic, methanolic and ethyl acetic extracts of , , and concerning the enzymatic inhibition assays revealed high anti-tyrosinase and anti-collagenase activities. From the isolated compounds tested, abietane diterpenes and triterpenes were highly active against tyrosinase and elastase activity. Overall, the experimental results showed the powerful antioxidant and inhibitory action on skin-related enzymes tyrosinase, collagenase and elastase of spp. extracts and/or isolated compounds, supporting their further research as bioactive metabolites against skin sagging and hyperpigmentation in cosmetic and pharmaceutical formulations.
从八个不同物种中获得了一系列植物提取物（水性、丙酮性、甲醇性和乙酸乙酯性）以及先前分离出的化合物（包括多酚、二萜和三萜），对其进行了抑制皮肤相关酶酪氨酸酶、胶原酶和弹性蛋白酶的测试，并研究了它们的抗氧化特性。[物种名称1]和[物种名称2]的乙酸乙酯提取物具有最高的抗氧化活性，而[物种名称3]、[物种名称4]、[物种名称5]和[物种名称6]的丙酮性、甲醇性和乙酸乙酯提取物在酶抑制试验中显示出高抗酪氨酸酶和抗胶原酶活性。在所测试的分离化合物中，枞烷二萜和三萜对酪氨酸酶和弹性蛋白酶活性具有高度活性。总体而言，实验结果表明[物种名称]提取物和/或分离化合物对皮肤相关酶酪氨酸酶、胶原酶和弹性蛋白酶具有强大的抗氧化和抑制作用，支持将其作为化妆品和药物制剂中对抗皮肤松弛和色素沉着的生物活性代谢物进行进一步研究。
