• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

大麻作用的神经分子机制。

Neuromolecular Mechanisms of Cannabis Action.

机构信息

University of Nottingham. Faculty of Medicine & Health Sciences, Nottingham, UK.

出版信息

Adv Exp Med Biol. 2021;1264:15-28. doi: 10.1007/978-3-030-57369-0_2.

DOI:10.1007/978-3-030-57369-0_2
PMID:33332001
Abstract

Most of our current understanding of the neuromolecular mechanisms of Cannabis action focusses on two plant cannabinoids, THC and CBD. THC acts primarily through presynaptic CB cannabinoid receptors to regulate neurotransmitter release in the brain, spinal cord and peripheral nerves. CBD action, on the other hand, is probably mediated through multiple molecular targets.

摘要

我们目前对大麻作用的神经分子机制的大部分理解都集中在两种植物大麻素,即 THC 和 CBD 上。THC 主要通过突触前 CB 大麻素受体来调节大脑、脊髓和外周神经中的神经递质释放。另一方面,CBD 的作用可能是通过多种分子靶标介导的。

相似文献

1
Neuromolecular Mechanisms of Cannabis Action.大麻作用的神经分子机制。
Adv Exp Med Biol. 2021;1264:15-28. doi: 10.1007/978-3-030-57369-0_2.
2
The diverse CB1 and CB2 receptor pharmacology of three plant cannabinoids: delta9-tetrahydrocannabinol, cannabidiol and delta9-tetrahydrocannabivarin.三种植物大麻素:Δ⁹-四氢大麻酚、大麻二酚和Δ⁹-四氢大麻萜酚的不同CB1和CB2受体药理学特性
Br J Pharmacol. 2008 Jan;153(2):199-215. doi: 10.1038/sj.bjp.0707442. Epub 2007 Sep 10.
3
Examining the role of cannabinoids on osteoporosis: a review.研究大麻素在骨质疏松症中的作用:综述
Arch Osteoporos. 2022 Nov 19;17(1):146. doi: 10.1007/s11657-022-01190-x.
4
Constituents of Cannabis Sativa.大麻的成分。
Adv Exp Med Biol. 2021;1264:1-13. doi: 10.1007/978-3-030-57369-0_1.
5
Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjects.健康人体受试者中,急性口服Δ9-四氢大麻酚和标准化大麻提取物与精神运动表现的关系。
Eur Arch Psychiatry Clin Neurosci. 2009 Aug;259(5):284-92. doi: 10.1007/s00406-009-0868-5. Epub 2009 Feb 17.
6
The loss of NMDAR-dependent LTD following cannabinoid self-administration is restored by positive allosteric modulation of CB1 receptors.大麻素自我给药后N-甲基-D-天冬氨酸受体(NMDAR)依赖性长时程抑制(LTD)的丧失可通过CB1受体的正向变构调节得以恢复。
Addict Biol. 2020 Nov;25(6):e12843. doi: 10.1111/adb.12843. Epub 2019 Nov 16.
7
A randomised controlled trial of vaporised Δ-tetrahydrocannabinol and cannabidiol alone and in combination in frequent and infrequent cannabis users: acute intoxication effects.一项随机对照试验研究了在频繁和不频繁使用大麻的人群中单独使用和联合使用蒸气化 Δ-四氢大麻酚和大麻二酚的效果:急性中毒效应。
Eur Arch Psychiatry Clin Neurosci. 2019 Feb;269(1):17-35. doi: 10.1007/s00406-019-00978-2. Epub 2019 Jan 19.
8
Effects of delta-9-tetrahydrocannabinol, 11-hydroxy-delta-9-tetrahydrocannabinol and cannabidiol on neuromuscular transmission in the frog.δ-9-四氢大麻酚、11-羟基-δ-9-四氢大麻酚和大麻二酚对青蛙神经肌肉传递的影响。
Neuropharmacology. 1986 Nov;25(11):1273-8. doi: 10.1016/0028-3908(86)90147-4.
9
Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L.大麻素类物质(如大麻二酚)对慢性不可预知温和应激模型大鼠的抗抑郁作用
Pharmacol Biochem Behav. 2010 Jun;95(4):434-42. doi: 10.1016/j.pbb.2010.03.004. Epub 2010 Mar 21.
10
Neuropharmacological Effects of the Main Phytocannabinoids: A Narrative Review.主要植物大麻素的神经药理学作用:叙事性综述。
Adv Exp Med Biol. 2021;1264:29-45. doi: 10.1007/978-3-030-57369-0_3.

引用本文的文献

1
Herbal extracts in orofacial pain: a systematic review and direct and indirect meta-analysis.草药提取物治疗口腔颌面部疼痛:系统评价及直接和间接的荟萃分析。
Sci Rep. 2024 Nov 29;14(1):29656. doi: 10.1038/s41598-024-77796-7.
2
The Use of Compounds Derived from in the Treatment of Epilepsy, Painful Conditions, and Neuropsychiatric and Neurodegenerative Disorders.在癫痫、疼痛病症以及神经精神和神经退行性疾病的治疗中使用来源于 的化合物。
Int J Mol Sci. 2024 May 25;25(11):5749. doi: 10.3390/ijms25115749.
3
The GPR18 Agonist PSB-KD-107 Exerts Endothelium-Dependent Vasorelaxant Effects.

本文引用的文献

1
Cannabidivarin completely rescues cognitive deficits and delays neurological and motor defects in male mutant mice.大麻二酚完全挽救了雄性突变小鼠的认知缺陷,并延缓了其神经和运动缺陷。
J Psychopharmacol. 2019 Jul;33(7):894-907. doi: 10.1177/0269881119844184. Epub 2019 May 14.
2
Identification and characterization of phytocannabinoids as novel dual PPARα/γ agonists by a computational and in vitro experimental approach.通过计算和体外实验方法鉴定和表征植物大麻素作为新型双重 PPARα/γ激动剂。
Biochim Biophys Acta Gen Subj. 2019 Mar;1863(3):586-597. doi: 10.1016/j.bbagen.2019.01.002. Epub 2019 Jan 3.
3
n-3 polyunsaturated N-acylethanolamines are CB cannabinoid receptor-preferring endocannabinoids.
GPR18激动剂PSB-KD-107发挥内皮依赖性血管舒张作用。
Pharmaceuticals (Basel). 2021 Aug 13;14(8):799. doi: 10.3390/ph14080799.
4
Effects of GPR18 Ligands on Body Weight and Metabolic Parameters in a Female Rat Model of Excessive Eating.GPR18配体对暴饮暴食雌性大鼠模型体重及代谢参数的影响
Pharmaceuticals (Basel). 2021 Mar 16;14(3):270. doi: 10.3390/ph14030270.
n-3 多不饱和 N-酰基乙醇胺是 CB 大麻素受体优先的内源性大麻素。
Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Nov;1863(11):1433-1440. doi: 10.1016/j.bbalip.2018.08.003. Epub 2018 Aug 7.
4
Cannabidiol's Upregulation of -acyl Ethanolamines in the Central Nervous System Requires -acyl Phosphatidyl Ethanolamine-Specific Phospholipase D.大麻二酚在中枢神经系统中上调酰基乙醇胺需要酰基磷脂酰乙醇胺特异性磷脂酶D。
Cannabis Cannabinoid Res. 2018 Nov 30;3(1):228-241. doi: 10.1089/can.2018.0031. eCollection 2018.
5
Effect of cannabidiolic acid and ∆-tetrahydrocannabinol on carrageenan-induced hyperalgesia and edema in a rodent model of inflammatory pain.大麻二酚酸和 ∆-9-四氢大麻酚对炎性疼痛啮齿动物模型中角叉菜胶诱导的痛觉过敏和水肿的影响。
Psychopharmacology (Berl). 2018 Nov;235(11):3259-3271. doi: 10.1007/s00213-018-5034-1. Epub 2018 Sep 17.
6
Involvement of glycine receptor α1 subunits in cannabinoid-induced analgesia.甘氨酸受体α1 亚基参与大麻素诱导的镇痛。
Neuropharmacology. 2018 May 1;133:224-232. doi: 10.1016/j.neuropharm.2018.01.041. Epub 2018 Feb 1.
7
Affinity and Efficacy Studies of Tetrahydrocannabinolic Acid A at Cannabinoid Receptor Types One and Two.四氢大麻酚酸A对大麻素1型和2型受体的亲和力及效能研究
Cannabis Cannabinoid Res. 2017 May 1;2(1):87-95. doi: 10.1089/can.2016.0032. eCollection 2017.
8
Tetrahydrocannabinolic acid is a potent PPARγ agonist with neuroprotective activity.四氢大麻酚酸是一种具有神经保护活性的强效 PPARγ 激动剂。
Br J Pharmacol. 2017 Dec;174(23):4263-4276. doi: 10.1111/bph.14019. Epub 2017 Nov 2.
9
Cannabinoid Receptor-Related Orphan G Protein-Coupled Receptors.大麻素受体相关孤儿G蛋白偶联受体
Adv Pharmacol. 2017;80:223-247. doi: 10.1016/bs.apha.2017.04.004. Epub 2017 Jun 12.
10
Crystal structures of agonist-bound human cannabinoid receptor CB.激动剂结合的人源大麻素受体CB的晶体结构
Nature. 2017 Jul 27;547(7664):468-471. doi: 10.1038/nature23272. Epub 2017 Jul 5.