Dias Isabella Rocha, Santos Carina de Sousa, Magalhães Caíque Olegário Diniz E, de Oliveira Lucas Renan Sena, Peixoto Marco Fabrício Dias, De Sousa Ricardo Augusto Leoni, Cassilhas Ricardo Cardoso
Neuroplasticity and Exercise Study Group (Grupo de Estudos em Neuroplasticidade e Exercício - GENE), UFVJM, Diamantina, MG, Brazil.
Multicenter Post Graduation Program in Physiological Sciences (PMPGCF), UFVJM, Brazilian Society of Physiology, Diamantina, MG, Brazil.
IBRO Rep. 2020 Jun 1;9:37-45. doi: 10.1016/j.ibror.2020.05.001. eCollection 2020 Dec.
Calorie restriction (CR) has been considered the most effective non-pharmacological intervention to counteract aging-related diseases and improve longevity. This intervention has shown beneficial effects in the prevention and treatment of several chronic diseases and functional declines related to aging, such as Parkinson's, Alzheimer's, and neuroendocrine disorders. However, the effects of CR on cognition show controversial results since its effects vary according to intensity, duration, and the period of CR. This review focuses on the main studies published in the last ten years regarding the consequences of CR on cognition in different neurological diseases and conditions of experimental animals. Also, possible CR mimetics are discussed. These findings highlight the potential beneficial effects of CR of up to 40 % on cognition when started early in life in non human animals.
卡路里限制（CR）被认为是对抗衰老相关疾病和延长寿命最有效的非药物干预措施。这种干预在预防和治疗几种与衰老相关的慢性疾病和功能衰退方面已显示出有益效果，如帕金森病、阿尔茨海默病和神经内分泌紊乱。然而，CR对认知的影响呈现出有争议的结果，因为其效果因强度、持续时间和CR时期的不同而有所差异。本综述聚焦于过去十年发表的关于CR对实验动物不同神经疾病和状况下认知影响的主要研究。此外，还讨论了可能的CR模拟物。这些发现凸显了在非人类动物生命早期开始高达40%的CR对认知的潜在有益影响。
