Departamento de Bioquímica-Alimentos, Facultad de Ciencias Químicas, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
Posgrado en Ciencias Químicas, BUAP, Puebla, Mexico.
Oxid Med Cell Longev. 2017;2017:8510761. doi: 10.1155/2017/8510761. Epub 2017 Oct 15.
The increase in the elderly population has generated concern to meet health demands. The research efforts to elucidate the mechanisms of damage associated with aging have also been significantly increased, especially in order to avoid the reduction of the cognitive abilities in geriatric patients, resulting from the damage generated mainly at the level of the hippocampus during old age. At present, many studies describe resveratrol as an antiaging component. There are reports that it can activate the Sirt1 gene related to antiaging, emulating the effects obtained by caloric restriction in rodents. The aim of the study was to evaluate the effect of chronic administration of resveratrol (10 mg/kg) on cognitive performance in behavioral tests after 8 months of treatment and on the preservation of cerebral integrity in the cytoarchitecture of regions CA1 and CA2. Results showed that the cytoarchitecture of the CA1 and CA2 regions in the hippocampus retained their integrity over time in rats treated with resveratrol, and the behavioral test performed revealed that chronic resveratrol administration for 8 months showed improvements in cognitive performance. The results indicate that resveratrol may exhibit therapeutic potential for age-related conditions.
人口老龄化的增加引起了人们对满足健康需求的关注。为了阐明与衰老相关的损伤机制，研究工作也有了显著的增加，特别是为了避免老年患者的认知能力因衰老主要在海马体水平引起的损伤而下降。目前，许多研究将白藜芦醇描述为一种抗衰老成分。有报道称，它可以激活与抗衰老相关的 Sirt1 基因，模拟在啮齿动物中通过热量限制获得的效果。本研究旨在评估慢性给予白藜芦醇（10mg/kg）在 8 个月治疗后对行为测试中认知表现的影响，以及对 CA1 和 CA2 区域细胞结构中脑完整性的保护作用。结果表明，在接受白藜芦醇治疗的大鼠中，海马体 CA1 和 CA2 区的细胞结构随时间保持完整，进行的行为测试显示，慢性白藜芦醇给药 8 个月可改善认知表现。结果表明，白藜芦醇可能对与年龄相关的疾病具有治疗潜力。
