Bayer Consumer Care AG, Peter-Merian-Straße 84, 4002 Basel, Switzerland.
Department Paediatrics, Division Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, LMU University Hospitals, Ludwig-Maximilians-Universität Munich, Lindwurmstraße 4, 80337 Munich, Germany.
Nutrients. 2020 Dec 16;12(12):3849. doi: 10.3390/nu12123849.
Breastfed infants require an adequate supply of critical nutrients for growth, tissue functions, and health. Recommended intakes for several nutrients are considerably higher in lactating than non-lactating women but are not always met with habitual diets. We report a randomized, double-blind clinical trial in 70 healthy lactating women in Germany evaluating the effects of supplementation with multiple micronutrients, lutein, and docosahexaenoic acid (DHA) compared to placebo on maternal nutrient status and milk composition. The primary endpoint was the effect on the change of human milk DHA content (as a proportion of total milk fatty acids) during 12 weeks of supplementation. Maternal blood and milk biomarkers were measured as secondary endpoints. Supplementation increased maternal milk DHA by 30% compared to a decline in the placebo group. Supplementation also increased maternal blood DHA (17%), eicosapentaenoic acid (4%), 25-OH-vitamin D (24%), vitamin B12 (12%), lutein (4%), and beta carotene (49%), while homocysteine decreased. No significant difference in the number of adverse events was observed between supplementation and placebo groups. In conclusion, multi-micronutrient supplementation was safe and increased maternal blood and milk concentrations of selected nutrients in healthy women.
母乳喂养的婴儿需要充足的关键营养素来促进生长、组织功能和健康。与非哺乳期妇女相比，推荐给哺乳期妇女的几种营养素摄入量要高得多，但在日常饮食中往往无法满足。我们报告了一项在德国进行的 70 名健康哺乳期妇女的随机、双盲临床试验，评估了与安慰剂相比，补充多种微量营养素、叶黄素和二十二碳六烯酸（DHA）对母亲营养状况和乳汁成分的影响。主要终点是在 12 周的补充期间对人乳 DHA 含量（占总乳脂肪酸的比例）变化的影响。母亲血液和乳汁生物标志物作为次要终点进行测量。与安慰剂组相比，补充剂使母乳 DHA 增加了 30%。补充剂还增加了母亲血液中的 DHA（17%）、二十碳五烯酸（4%）、25-羟维生素 D（24%）、维生素 B12（12%）、叶黄素（4%）和β-胡萝卜素（49%），同时降低了同型半胱氨酸水平。补充剂组和安慰剂组之间观察到的不良事件数量没有显著差异。总之，多种微量营养素补充剂是安全的，并增加了健康女性血液和乳汁中选定营养素的浓度。
