Chu Ying, Chang Yi, Lu Wei, Sheng Xiumei, Wang Shengjun, Xu Huaxi, Ma Jie
Department of Immunology, Jiangsu Key Laboratory of Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, People's Republic of China.
Cancer Manag Res. 2020 Dec 23;12:13259-13271. doi: 10.2147/CMAR.S279672. eCollection 2020.
Autophagy is a critical cellular process that generally protects cells and organisms from harsh environment, including limitations in adenosine triphosphate (ATP) availability or a lack of essential nutrients. Metabolic reprogramming, a hallmark of cancer, has recently gained interest in the area of cancer therapy. It is well known that cancer cells prefer to utilize glycolysis rather than oxidative phosphorylation (OXPHOS) as their major energy source to rapidly generate ATP even in aerobic environment called the Warburg effect. Both autophagy and glycolysis play essential roles in pathological processes of cancer. A mechanism of metabolic changes to drive tumor progression is its ability to regulate autophagy. This review will elucidate the role and the mechanism of glycolysis in regulating autophagy during tumor growth. Indeed, understanding how glycolysis can modulate cellular autophagy will enable more effective combinatorial therapeutic strategies.
自噬是一种关键的细胞过程，通常可保护细胞和生物体免受恶劣环境的影响，包括三磷酸腺苷（ATP）供应受限或缺乏必需营养素。代谢重编程是癌症的一个标志，最近在癌症治疗领域引起了关注。众所周知，癌细胞即使在有氧环境（即瓦伯格效应）中也更喜欢利用糖酵解而非氧化磷酸化（OXPHOS）作为其主要能量来源来快速生成ATP。自噬和糖酵解在癌症的病理过程中都起着重要作用。代谢变化驱动肿瘤进展的一种机制是其调节自噬的能力。本综述将阐明糖酵解在肿瘤生长过程中调节自噬的作用和机制。事实上，了解糖酵解如何调节细胞自噬将有助于制定更有效的联合治疗策略。
