Bhattacharyya Parthasarathi
Department of Paediatric Haemato-Oncology, Paediatric Onco-Critical Care Unit, Tata Medical Center, Kolkata, West Bengal, India.
Indian J Crit Care Med. 2020 Nov;24(11):1010-1011. doi: 10.5005/jp-journals-10071-23652.
Severe acute respiratory syndrome-coronavirus-2 (SARS CoV-2) is a novel virus. There has been an increasing number of case reports on multisystem inflammatory syndrome in children (MIS-C) but the global and population-specific incidence of MIS-C particularly in Asian countries, its causal relationship with SARS-CoV-2 and its immunopathogenesis remain unknown. Emerging questions on how the pathophysiology of MIS-C differs from that of Kawasaki disease (KD) and non-KD inflammatory syndromes need to be answered. Genetic factors influencing the incidence of MIS-C in the different ethnic populations are to be explored. What happens to the children with MIS-C, in the long run, remains unknown to date. Multicenter clinical trials are needed to establish optimal treatment and follow-up for MIS-C.
Bhattacharyya P. Multisystem Inflammatory Syndrome of Children Related to SARS-CoV-2: A Novel Experience in Children with a Novel Virus. Indian J Crit Care Med 2020;24(11):1010-1011.
严重急性呼吸综合征冠状病毒2（SARS-CoV-2）是一种新型病毒。儿童多系统炎症综合征（MIS-C）的病例报告越来越多，但MIS-C在全球及特定人群中的发病率，尤其是在亚洲国家，其与SARS-CoV-2的因果关系及其免疫发病机制仍不清楚。关于MIS-C的病理生理学与川崎病（KD）和非KD炎症综合征的病理生理学有何不同这一新兴问题有待解答。需要探索影响不同种族人群中MIS-C发病率的遗传因素。从长远来看，MIS-C患儿的情况至今仍不清楚。需要进行多中心临床试验来确定MIS-C的最佳治疗和随访方案。
Bhattacharyya P. 与SARS-CoV-2相关的儿童多系统炎症综合征：感染新型病毒儿童的新情况。《印度危重症医学杂志》2020年；24(11):1010 - 1011。
