Pushpagiri Research Centre, Pushpagiri Institute of Medical Sciences and Research Centre, Tiruvalla, Kerala- 689101, India.
Curr Drug Targets. 2021;22(11):1272-1287. doi: 10.2174/1389450121999201230204526.
Medicinal plants and mushrooms have always fascinated the world as an attractive source of natural compounds for cancer therapy. From ancient times, they have been valued as gourmet food and folk medicine in Oriental practice. For over 40 years, the world has witnessed the overwhelming interest of the western scientific fraternity in the pharmaceutical potential of natural products in combating cancer. The plants and mushrooms credited with success against angiogenesis and cancer metastasis belong to certain Plants, including Catharanthus roseus, Aloe Vera,Annona muricata,Curcuma longa, Withania somnifera, and Berberis and mushrooms such as Agaricus, Antrodia, Ganoderma, Grifolafrondosa, Hericiumerinaceus, Phellinuslinteus, and Trametesversicolor Coriolusversicolor. The anti-cancer compounds play a pivotal role as a free radical scavenger and reactive oxygen species inducer, mitotic spindle kinase inhibitor, anti-mitotic, angiogenesis inhibitor, topoisomerase inhibitor, apoptosis inducers, and eventually checking cancer invasion, migration and proliferation. The present review updates and focuses on the recent findings of the pharmacologically potential bioactive compounds, their anti-tumor potential, and underlying mechanism of preventing cancer metastasis and angiogenesis in order to raise knowledge for further investigations to develop cancer therapeutics with no adverse side effects The mounting experimental evidence at pre-clinical and clinical levels from various research groups across the globe, regarding prevention of cancer metastasis by natural products unarguably make it a fast-track research area worth mass attention.
药用植物和蘑菇一直以来都是世界关注的焦点，它们是癌症治疗中天然化合物的极具吸引力的来源。自古以来，它们就被视为东方美食和民间药物而备受推崇。四十多年来，世界见证了西方科学界对天然产物在抗癌方面的药物潜力的浓厚兴趣。被认为具有抗血管生成和癌症转移作用的植物和蘑菇属于某些植物，包括长春花、芦荟、番木瓜、姜黄、南非醉茄和小檗属，以及蘑菇如灵芝、冬虫夏草、灵芝、灰树花、猴头菇、云芝和云芝。抗癌化合物作为自由基清除剂和活性氧诱导剂、有丝分裂纺锤体激酶抑制剂、抗有丝分裂、血管生成抑制剂、拓扑异构酶抑制剂、凋亡诱导剂发挥着关键作用，最终可以阻止癌症的侵袭、迁移和增殖。本综述更新并重点介绍了最近发现的具有药理潜力的生物活性化合物，它们的抗肿瘤潜力以及预防癌症转移和血管生成的潜在机制，以期为进一步研究开发无不良反应的癌症治疗方法提供知识。全球各地的不同研究小组在临床前和临床水平上积累的越来越多的实验证据，无可争议地使天然产物预防癌症转移成为一个值得关注的快速发展的研究领域。
