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长链非编码 RNA linc00673 作为一种新型肿瘤调控 lncRNA 的研究进展。

A review of linc00673 as a novel lncRNA for tumor regulation.

机构信息

Department of Head and Neck Surgery, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

NHC Key Laboratory of Carcinogenesis, and Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, Central South University, Changsha, Hunan, China.

出版信息

Int J Med Sci. 2021 Jan 1;18(2):398-405. doi: 10.7150/ijms.48134. eCollection 2021.

Abstract

Long non-coding RNAs (LncRNAs) act as regulators and play important roles in a variety of biological processes. These regulators constitute a huge information network among genes and participate in the pathophysiological process of human diseases. Increasing evidence has demonstrated that LncRNA, as an oncogene or tumor suppressor gene, is closely related to the occurrence and development of tumors. Linc00673 is a recently discovered LncRNA molecule that is dysregulated in several solid tumors. Moreover, its genetic polymorphism is believed to affect the susceptibility of a population to the corresponding cancer species. This article summarizes the role of Linc00673 in different human cancers and its molecular mechanisms with a focus on the characteristics of Linc00673 and the existing literature on it while highlighting the future research directions for Linc00673. Linc00673 has the potential to become a feasible clinical diagnostic and prognostic marker toward providing a new molecular therapeutic target for cancer patients.

摘要

长链非编码 RNA(lncRNAs)作为调控因子,在多种生物学过程中发挥重要作用。这些调控因子在基因之间构成了庞大的信息网络,并参与人类疾病的病理生理过程。越来越多的证据表明,lncRNA 作为癌基因或肿瘤抑制基因,与肿瘤的发生和发展密切相关。Linc00673 是一种最近发现的 lncRNA 分子,在几种实体肿瘤中失调。此外,其遗传多态性被认为会影响人群对相应癌症的易感性。本文总结了 Linc00673 在不同人类癌症中的作用及其分子机制,重点介绍了 Linc00673 的特征和现有文献,并强调了 Linc00673 的未来研究方向。Linc00673 有可能成为一种可行的临床诊断和预后标志物,为癌症患者提供新的分子治疗靶点。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b8d7/7757132/fea07628a1a3/ijmsv18p0398g001.jpg

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