Department of Periodontics, College of Dentistry, University of Illinois at Chicago, Chicago, IL, USA.
Department of Oral Medicine and Diagnostics, College of Dentistry, University of Illinois at Chicago, 801 South Paulina Street, Chicago, IL, 60612, USA.
Sci Rep. 2021 Jan 8;11(1):188. doi: 10.1038/s41598-020-80170-y.
The effect of oral microbial composition on periodontal health and on systemic health has been, and is being established. The oral microbiome, in turn, can be altered by local and systemic diseases and conditions. Gastroesophageal reflux disease (GERD), has been associated with increased acidity in the oral cavity resulting in dental erosion, and controversially a reduced risk of periodontal disease. We hypothesized that presence of GERD was linked to a modified microbial profile in untreated GERD patients and that the use of proton pump inhibitor (PPI) drugs: potent disruptors of gut microbiome, in GERD patients might result in a salivary microbiome that is further distinct. Untreated GERD patients showed multiple differences in salivary microbiome as compared to healthy controls. Taxa found at lower levels related to the presence of GERD not treated by PPI included: Prevotella melaninogenica, Prevotella pallens, Leptotrichia, and Solobacterium moorei and thirteen others. In contrast, GERD patients chronically using PPI showed minimal differences in salivary taxa compared to healthy controls not using PPI.
口腔微生物组成对牙周健康和全身健康的影响已经得到证实。口腔微生物组反过来也可以被局部和全身疾病和状况所改变。胃食管反流病（GERD）与口腔内酸度增加有关，导致牙齿侵蚀，并且有争议的是牙周病的风险降低。我们假设 GERD 的存在与未经治疗的 GERD 患者的微生物特征改变有关，并且 GERD 患者使用质子泵抑制剂（PPI）药物——肠道微生物组的强效破坏剂——可能导致唾液微生物组进一步明显不同。与未经 PPI 治疗的 GERD 相关的低水平存在的分类群包括：普雷沃氏菌属黑色素原种、普雷沃氏菌属苍白亚种、勒特氏菌属和索氏梭杆菌，以及其他十三种。相比之下，长期使用 PPI 的 GERD 患者与未使用 PPI 的健康对照组相比，唾液分类群的差异最小。
