Souihel Selma, Cessac Bruno
Biovision Team and Neuromod Institute, Inria, Université Côte d'Azur, Nice, France.
J Math Neurosci. 2021 Jan 9;11(1):3. doi: 10.1186/s13408-020-00101-z.
We analyse the potential effects of lateral connectivity (amacrine cells and gap junctions) on motion anticipation in the retina. Our main result is that lateral connectivity can-under conditions analysed in the paper-trigger a wave of activity enhancing the anticipation mechanism provided by local gain control (Berry et al. in Nature 398(6725):334-338, 1999; Chen et al. in J. Neurosci. 33(1):120-132, 2013). We illustrate these predictions by two examples studied in the experimental literature: differential motion sensitive cells (Baccus and Meister in Neuron 36(5):909-919, 2002) and direction sensitive cells where direction sensitivity is inherited from asymmetry in gap junctions connectivity (Trenholm et al. in Nat. Neurosci. 16:154-156, 2013). We finally present reconstructions of retinal responses to 2D visual inputs to assess the ability of our model to anticipate motion in the case of three different 2D stimuli.
我们分析了视网膜中横向连接(无长突细胞和缝隙连接)对运动预测的潜在影响。我们的主要结果是,在本文所分析的条件下,横向连接能够引发一波活动,增强由局部增益控制所提供的预测机制(Berry等人,《自然》,398(6725):334 - 338,1999年;Chen等人,《神经科学杂志》,33(1):120 - 132,2013年)。我们通过实验文献中研究的两个例子来说明这些预测:差分运动敏感细胞(Baccus和Meister,《神经元》,36(5):909 - 919,2002年)以及方向敏感性从缝隙连接连接的不对称性遗传而来的方向敏感细胞(Trenholm等人,《自然神经科学》,16:154 - 156,2013年)。我们最后展示了视网膜对二维视觉输入的反应重建,以评估我们的模型在三种不同二维刺激情况下预测运动的能力。