University of Hudderfield, Huddersfield, UK.
South West Yorkshire Partnership NHS Foundation Trust, Wakefield, UK.
BMC Psychiatry. 2021 Jan 10;21(1):24. doi: 10.1186/s12888-020-03028-7.
The Autism Diagnostic Observation Schedule, Second Edition (ADOS-2) module four assessment for diagnosing autism spectrum disorder in adults has shown good sensitivity and specificity in research settings.
This study aimed to evaluate the predictive accuracy of the ADOS-2 module four by investigating the components of the assessment, in relation to diagnostic outcome in a clinical setting. Data from 88 service users referred to a Specialist Adult Autism Service was explored.
ADOS-2 scores failed to predict the diagnostic outcome (overall sensitivity = 92%, specificity = 57%). Interestingly, scores from the 'restricted interests' component of the ADOS-2 have the potential to predict diagnostic outcome, despite this domain not been included in the scoring algorithm.
Based on our findings, we recommend clinicians are cautious when interpreting results of the ADOS-2 assessment.
用于诊断成人自闭症谱系障碍的自闭症诊断观察量表第二版（ADOS-2）第四模块评估在研究环境中显示出了良好的灵敏度和特异性。
本研究旨在通过研究评估的组成部分，评估 ADOS-2 第四模块的预测准确性，从而在临床环境中研究诊断结果。研究人员调查了 88 名被转介至专业成人自闭症服务机构的服务使用者的数据。
ADOS-2 评分未能预测诊断结果（整体灵敏度=92%，特异性=57%）。有趣的是，ADOS-2 中“受限兴趣”这一组成部分的评分具有预测诊断结果的潜力，尽管这一领域未包含在评分算法中。
根据我们的研究结果，我们建议临床医生在解释 ADOS-2 评估结果时要谨慎。
