Cui Lei, Hou Na-Na, Wu Hong-Mei, Zuo Xiang, Lian Yi-Zhi, Zhang Chao-Nan, Wang Zhen-Feng, Zhang Xiong, Zhu Jian-Hong
Department of Geriatrics and Neurology, The Second Affiliated Hospital and Yuying Children's Hospital, Wenzhou Medical University, Wenzhou, China.
Department of Preventive Medicine, Wenzhou Medical University, Wenzhou, China.
Front Aging Neurosci. 2020 Dec 21;12:603854. doi: 10.3389/fnagi.2020.603854. eCollection 2020.
Alzheimer's disease (AD) and Parkinson's disease (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress in China. Up-to-date estimates of AD and PD prevalence have not been provided. Studies that reported the prevalence of AD and PD in China were identified via a systematic database search from 1985 to 2018. Meta-analysis, local polynomial regression and autoregressive integrated moving average model were used for analyses. A total of 99 studies were included in the study with populations of 385,312 and 227,228, respectively for AD and PD. The overall prevalence of AD and PD following age standardization was 3.20% [95% confidence interval (CI) = 3.17-3.23] and 1.06% (95% CI = 1.02-1.10), respectively in individuals over 60 years old. The rates increased drastically for every 10-years increment of age. The yearly prevalence of AD was predicted to increase from 3.81 to 6.17% in the next 5 years. Significant differences were observed between genders [male to female odds ratio (OR) for AD = 0.57, 95% CI = 0.51-0.64; OR for PD = 1.25, 95% CI = 1.06-1.46], and between education levels (Illiterate to non-illiterate OR for AD = 2.99, 95% CI = 2.38-3.75), but not between urban and rural settings. Our results provide an updated insight into the epidemiology of AD and PD in China and their associated rates and ratios. The findings may facilitate China policy makers and health professionals mitigate the related health issues.
阿尔茨海默病（AD）和帕金森病（PD）是全球范围内两种主要的神经退行性疾病。中国的人口老龄化进程正在加速。目前尚未提供AD和PD患病率的最新估计数据。通过对1985年至2018年的系统数据库搜索，确定了报告中国AD和PD患病率的研究。采用荟萃分析、局部多项式回归和自回归积分移动平均模型进行分析。该研究共纳入99项研究，AD和PD的研究对象分别为385,312人和227,228人。60岁以上人群中，AD和PD经年龄标准化后的总体患病率分别为3.20%[95%置信区间（CI）=3.17-3.23]和1.06%（95%CI=1.02-1.10）。患病率随年龄每增加10岁而急剧上升。预计未来5年AD的年患病率将从3.81%升至6.17%。在性别之间[AD的男性与女性优势比（OR）=0.57，95%CI=0.51-0.64；PD的OR=1.25，95%CI=1.06-1.46]以及教育水平之间（AD文盲与非文盲的OR=2.99，95%CI=2.38-3.75）存在显著差异，但城乡之间没有差异。我们的结果为中国AD和PD的流行病学及其相关发病率和比率提供了最新见解。这些发现可能有助于中国政策制定者和卫生专业人员缓解相关健康问题。
