儿童饮食行为的基因组学。
The genomics of childhood eating behaviours.
机构信息
Great Ormond Street Institute of Child Health, University College London, London, UK.
Department of Biostatistics & Health Informatics, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK.
出版信息
Nat Hum Behav. 2021 May;5(5):625-630. doi: 10.1038/s41562-020-01019-y. Epub 2021 Jan 11.
Eating behaviours may be expressions of genetic risk for obesity and are potential antecedents of later eating disorders. However, childhood eating behaviours are heterogeneous and transient. Here we show associations between polygenic scores for body mass index (BMI-PGS) and anorexia nervosa (AN-PGS) with eating behaviour trajectories during the first 10 years of life using data from the Avon Longitudinal Study of Parents and Children (ALSPAC), n = 7,825. Results indicated that 1 s.d. increase in the BMI-PGS was associated with a 30-37% increased risk for early- and mid-childhood overeating. In contrast, 1 s.d. increase in BMI-PGS was associated with a 20% decrease in risk of persistent high levels of undereating and a 15% decrease in risk of persistent fussy eating. There was no evidence for a significant association between AN-PGS and eating behaviour trajectories. Our results support the notion that child eating behaviours share common genetic variants associated with BMI.
饮食习惯可能是肥胖遗传风险的表现，也是日后饮食失调的潜在前兆。然而，儿童饮食习惯具有异质性和短暂性。在这里，我们利用阿冯纵向研究父母和子女（ALSPAC）的数据，展示了体质指数多基因评分（BMI-PGS）和神经性厌食症多基因评分（AN-PGS）与生命最初 10 年的饮食行为轨迹之间的关联，n=7825。结果表明，BMI-PGS 增加 1 个标准差与儿童早期和中期过度饮食的风险增加 30-37%相关。相比之下，BMI-PGS 增加 1 个标准差与持续高水平的进食不足风险降低 20%和持续挑食风险降低 15%相关。AN-PGS 与饮食行为轨迹之间没有显著关联的证据。我们的研究结果支持这样一种观点，即儿童的饮食行为存在与 BMI 相关的共同遗传变异。
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