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海洋微藻 sp. SABC 012504 的具有抗炎和抗血栓活性的生物活性脂质。

Bioactive Lipids of Marine Microalga sp. SABC 012504 with Anti-Inflammatory and Anti-Thrombotic Activities.

机构信息

Shannon Applied Biotechnology Centre, Limerick Institute of Technology, Moylish Park, V94 E8YF Limerick, Ireland.

Department of Biological Sciences, University of Limerick, V94 T9PX Limerick, Ireland.

出版信息

Mar Drugs. 2021 Jan 10;19(1):28. doi: 10.3390/md19010028.

DOI:10.3390/md19010028
PMID:33435162
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7827044/
Abstract

Microalgae are at the start of the food chain, and many are known producers of a significant amount of lipids with essential fatty acids. However, the bioactivity of microalgal lipids for anti-inflammatory and antithrombotic activities have rarely been investigated. Therefore, for a sustainable source of the above bioactive lipids, the present study was undertaken. The total lipids of microalga sp., isolated from the Irish coast, were fractionated into neutral-, glyco-, and phospho-lipids, and were tested in vitro for their anti-inflammatory and antithrombotic activities. All tested lipid fractions showed strong anti-platelet-activating factor (PAF) and antithrombin activities in human platelets (half maximal inhibitory concentration (IC) values ranging ~25-200 μg of lipid) with the highest activities in glyco- and phospho-lipid fractions. The structural analysis of the bioactive lipid fraction-2 revealed the presence of specific sulfoquinovosyl diacylglycerols (SQDG) bioactive molecules and the HexCer-t36:2 (t18:1/18:1 and 18:2/18:0) cerebrosides with a phytosphingosine (4-hydrosphinganine) base, while fraction-3 contained bioactive phosphatidylcholine (PC) and phosphatidylethanolamine (PE) molecules. These novel bioactive lipids of sp. with putative health benefits may indicate that marine microalgae can be a sustainable alternative source for bioactive lipids production for food supplements and nutraceutical applications. However, further studies are required towards the commercial technology pathways development and biosafety analysis for the use of the microalga.

摘要

微藻处于食物链的起点，许多微藻被公认为是大量具有必需脂肪酸的脂类的生产者。然而，微藻脂类的抗炎和抗血栓活性的生物活性很少被研究过。因此，为了获得具有上述生物活性的脂类的可持续来源，进行了本研究。从爱尔兰海岸分离的微藻 sp.的总脂类被分为中性脂类、糖脂类和磷酯类，并在体外测试其抗炎和抗血栓活性。所有测试的脂类均显示出对人血小板强烈的抗血小板活化因子（PAF）和抗凝血酶活性（半数最大抑制浓度（IC）值范围为~25-200μg 脂类），糖脂类和磷酯类的活性最高。生物活性脂类部分-2 的结构分析表明存在特定的硫酸奎诺糖基二酰基甘油（SQDG）生物活性分子和 HexCer-t36:2（t18:1/18:1 和 18:2/18:0）神经酰胺，而部分-3 含有生物活性的磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）分子。sp. 的这些新型生物活性脂类具有潜在的健康益处，这表明海洋微藻可以成为生物活性脂类生产的可持续替代来源，用于食品补充剂和营养保健品应用。然而，需要进一步研究以开发商业技术途径，并对微藻的使用进行生物安全性分析。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/5142adb2404f/marinedrugs-19-00028-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/eceb44fc1f71/marinedrugs-19-00028-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/f1593318f400/marinedrugs-19-00028-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/dcddbb3c82f5/marinedrugs-19-00028-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/d198280cf8a4/marinedrugs-19-00028-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/5142adb2404f/marinedrugs-19-00028-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/eceb44fc1f71/marinedrugs-19-00028-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/f1593318f400/marinedrugs-19-00028-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/dcddbb3c82f5/marinedrugs-19-00028-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/d198280cf8a4/marinedrugs-19-00028-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/80db/7827044/5142adb2404f/marinedrugs-19-00028-g005.jpg

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