Research Center for Food Hygiene and Safety, School of Public Health, Shahid Sadoughi University of Medical Sciences, Shohadaye Gomnam Blvd., Yazd, 8916188638, Islamic Republic of Iran.
Department of Pathology, Medical University of Isfahan, Isfahan, Iran.
Sci Rep. 2021 Jan 13;11(1):1126. doi: 10.1038/s41598-021-80958-6.
Rice is considered one of the most important staple food crops. Genetically modified (GM) Bt rice, harbored cry1Ab gene expressing the insect-resistance protein has been developed to resistance to the insects. In this study, we assessed the safety of the GM Bt rice on Sprague-Dawley rats for 90 days. Totally, 120 rats in both sexes were used for three different diets, including 50% GM Bt rice, feeding with 50% rice, and standard feeding. Each 40 SD rats including 20 males and 20 females were considered as each diet. The clinical variables such as body weight and food consumption were measured and a range of clinical tests was examined, including hematology, serum chemistry parameters, urinalysis profile, thyroid, and sex hormone levels. Pathological assessments were also done. The results showed that the mean weekly feed utilization (%) had no significant difference among the studied groups. Also, blood biochemistry, hematological parameters, urine analysis, and hormonal levels had no significant differences among the groups. However, alanine aminotransferase was less in males versus female feeding with GM Bt rice. No histopathological changes were observed among the groups. In conclusion, this study demonstrated that GM Bt rice had no obvious adverse effects on rats' health.
大米被认为是最重要的主食之一。为了抗虫，已经开发出了携带 cry1Ab 基因（表达抗虫蛋白）的转基因抗虫水稻（Bt 水稻）。在这项研究中，我们评估了转 Bt 基因水稻对 Sprague-Dawley 大鼠 90 天的安全性。总共使用了 120 只雌雄大鼠进行了三种不同的饮食实验，包括 50%的转 Bt 水稻，50%的普通水稻，和标准饮食。每 40 只 SD 大鼠（包括 20 只雄性和 20 只雌性）作为一个饮食组。测量了临床变量，如体重和食物摄入量，并进行了一系列的临床检查，包括血液学、血清化学参数、尿液分析、甲状腺和性激素水平。还进行了病理学评估。结果表明，研究组之间的平均每周饲料利用率（%）没有显著差异。此外，血液生化、血液学参数、尿液分析和激素水平在各组之间也没有显著差异。然而，与食用普通水稻的雄性大鼠相比，食用转 Bt 水稻的雄性大鼠的丙氨酸氨基转移酶水平较低。各组之间没有观察到组织病理学变化。总之，本研究表明，转 Bt 基因水稻对大鼠的健康没有明显的不良影响。
