Department of Thyroid and Breast Surgery, Xi'an No. 3 Hospital, The Affiliated Hospital of Northwest University, Fengcheng 3rd Road 10, Weiyang District, Xi'an, Shaanxi 710018, P. R. China.
Department of Radiotherapy, The First Affiliated Hospital of Xi'an Jiaotong University, Yanta West Road 277, Yanta District, Xi'an, Shaanxi 710061, P. R. China.
Biosci Rep. 2021 Feb 26;41(2). doi: 10.1042/BSR20203121.
Triple-negative breast cancer (TNBC) is the most malignant and fatal subtype of breast cancer, which has characterized by negativity expression of ER, PR, and HER2. Metastasis is the main factor affecting the prognosis of TNBC, and the process of metastasis is related to abnormal activation of epithelial-mesenchymal transition (EMT). Recent studies have shown that long non-coding RNA (LncRNA) plays an important role in regulating the metastasis and invasion of TNBC. Therefore, based on the metastasis-related EMT signaling pathway, great efforts have confirmed that LncRNA is involved in the molecular mechanism of TNBC metastasis, which will provide new strategies to improve the treatment and prognosis of TNBC. In this review, we summarized many signal pathways related to EMT involved in the transfer process. The advances from the most recent studies of lncRNAs in the EMT-related signal pathways of TNBC metastasis. We also discussed the clinical research, application, and challenges of LncRNA in TNBC.
三阴性乳腺癌（TNBC）是乳腺癌中最恶性和致命的亚型，其特征为 ER、PR 和 HER2 的阴性表达。转移是影响 TNBC 预后的主要因素，而转移过程与上皮-间充质转化（EMT）的异常激活有关。最近的研究表明，长链非编码 RNA（LncRNA）在调节 TNBC 的转移和侵袭中发挥重要作用。因此，基于转移相关的 EMT 信号通路，大量研究已经证实 LncRNA 参与了 TNBC 转移的分子机制，这将为改善 TNBC 的治疗和预后提供新的策略。在这篇综述中，我们总结了 EMT 转移过程中涉及的许多信号通路。讨论了 LncRNA 在 TNBC 转移的 EMT 相关信号通路中的最新研究进展。我们还讨论了 LncRNA 在 TNBC 中的临床研究、应用和挑战。
