COpenhagen Prospective Studies on Asthma in Childhood (COPSAC), Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark; Department of Pediatrics, Slagelse Sygehus, Slagelse, Denmark.
Krefting Research Centre, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden; Wallenberg Centre for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden.
J Allergy Clin Immunol. 2021 Apr;147(4):1164-1173. doi: 10.1016/j.jaci.2020.12.640. Epub 2021 Jan 11.
Furry mammals kept as pets are important allergen sources. The prevalence of sensitization to dander from various animals appears to be increasing worldwide. Several mammalian allergens from diverse species and distinct protein families have been characterized, and some are available for component-resolved diagnostics (CRD). This review presents an overview of mammalian aeroallergens, with a focus on cat, dog, and horse allergens. The potential of CRD in fine-tuning the diagnostic workup following traditional methods based on whole- allergen extracts and allergen immunotherapy is discussed. The review highlights the clinical utility of CRD, particularly as a marker/predictor of increased asthma risk and disease severity. Finally, several perspectives of the future implications of CRD are offered in the context of furry animal allergens.
宠物饲养的毛茸茸哺乳动物是重要的过敏原来源。全球范围内，对各种动物皮屑致敏的患病率似乎在不断增加。已经鉴定出来自不同物种和不同蛋白质家族的几种哺乳动物过敏原，其中一些可用于成分分辨诊断（CRD）。本文综述了哺乳动物气传过敏原，重点介绍了猫、狗和马过敏原。讨论了 CRD 在传统基于全过敏原提取物和过敏原免疫治疗的诊断方法之后进行精细调整诊断的潜力。本文强调了 CRD 的临床实用性，特别是作为哮喘风险和疾病严重程度增加的标志物/预测因子。最后，在毛茸茸动物过敏原的背景下，提供了 CRD 未来意义的几个观点。
