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石墨烯量子点在乳腺癌中的治疗诊断前景。

Theranostic Prospects of Graphene Quantum Dots in Breast Cancer.

机构信息

Department of Pharmaceutical Chemistry, H. R. Patel Institute of Pharmaceutical Education and Research, Shirpur-425405, Maharashtra, India.

出版信息

ACS Biomater Sci Eng. 2020 Nov 9;6(11):5987-6008. doi: 10.1021/acsbiomaterials.0c01045. Epub 2020 Oct 26.

Abstract

Breast cancer (BC) is increasing as a significant cause of mortality among women. In this context, early diagnosis and treatment strategies for BC are being developed by researchers at the cellular level using advanced nanomaterials. However, immaculate etiquette is the prerequisite for their implementation in clinical practice. Considering the stolid nature of cancer, combining diagnosis and therapy (theranostics) using graphene quantum dots (GQDs) is a prime focus and challenge for researchers. In a nutshell, GQDs is a new shining star among various fluorescent materials, which has acclaimed fame in a short duration in materials science and the biomedical field as well. From this perspective, we review various strategies in BC treatment using GQDs alone or in combination. In addition, the photophysical properties of GQDs explored in photothermal therapy, hyperthermia therapy, and photodynamic therapy are also discussed. Moreover, we also focus on the strategic use of GQDs both as drug carriers and as combinatorial-guided drug delivery motifs. This Review provides an update for the scientific community to plan and expand advanced theranostic horizons in BC using GQDs.

摘要

乳腺癌(BC)是女性死亡的主要原因之一,发病率不断上升。在此背景下,研究人员正从细胞层面利用先进的纳米材料来开发针对 BC 的早期诊断和治疗策略。然而,在将其应用于临床实践之前,必须先确保其具备完美的应用规范。鉴于癌症的顽固特性,利用石墨烯量子点(GQDs)进行诊断和治疗的联合(即治疗诊断学)是研究人员的主要关注点和挑战。简而言之,GQDs 是各种荧光材料中的一颗新星,在材料科学和生物医学领域,它在短时间内获得了盛誉。从这个角度来看,我们综述了单独使用或联合使用 GQDs 治疗 BC 的各种策略。此外,还探讨了 GQDs 在光热疗法、热疗和光动力疗法中的光物理特性。此外,我们还重点关注了 GQDs 作为药物载体和组合引导药物输送基序的战略应用。本综述为科学界提供了最新信息,以便使用 GQDs 规划和扩展 BC 的先进治疗诊断学领域。

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