Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, Liaoning, PR China.
School of Functional Food and Wine, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, Liaoning, PR China.
J Control Release. 2021 May 10;333:41-64. doi: 10.1016/j.jconrel.2021.01.010. Epub 2021 Jan 12.
For the past few years, nanotechnology has provided a lot of new treatment opportunities for prostate cancer patients, and brilliant achievements have been acquired indeed. It not only prolonged circulation time in vivo but also increased bio-availability of drugs. Among them, nanoparticles with specificity ligand can be better targeted at prostate cancer, which improves the curative effect and reduces side effects. What's more, in terms of combined administration, the synergistic effect of chemotherapeutic drugs and hormones, or co-delivery two or more different drugs into the same delivery system, has achieved good therapeutic progress as well. In this paper, a comprehensive overview of nano-technology and the combination therapy for prostate cancer by pharmaceutical and clinical pharmaceutical strategies have been proposed to further appreciate and recommend the design and development of prostate cancer treatment.
在过去的几年中，纳米技术为前列腺癌患者提供了许多新的治疗机会，并且确实取得了辉煌的成就。它不仅延长了药物在体内的循环时间，而且提高了药物的生物利用度。其中，具有特异性配体的纳米粒子可以更好地针对前列腺癌，从而提高疗效并降低副作用。此外，在联合给药方面，化疗药物和激素的协同作用，或者将两种或更多种不同的药物共同递送到同一个递药系统中，也取得了良好的治疗进展。本文通过药物制剂和临床药剂学策略，对纳米技术在前列腺癌中的应用及联合治疗进行了综述，以期对前列腺癌的治疗设计和开发提出建议。
