Engineering Research Center of Molecular and Neuro Imaging, Ministry of Education, School of Life Science and Technology, Xidian University, Xi'an, Shaanxi 710126, P. R. China.
Interdisciplinary Research Center of Smart Sensor, School of Advanced Materials and Nanotechnology, Xidian University, Xi'an, Shaanxi 710126, P. R. China.
ACS Biomater Sci Eng. 2020 Sep 14;6(9):4940-4948. doi: 10.1021/acsbiomaterials.0c00984. Epub 2020 Sep 1.
The synergistic treatment through multiple treatment methods can effectively improve the effect of tumor treatment. Phototherapy and immunotherapy are two innovative and promising cancer diagnosis and treatment methods, so they are good candidates for collaborative diagnosis and treatment. Here we report a new inorganic nanosystem, which uses ultrathin black phosphorus (BP) nanosheets (minimum: 13 nm) as carriers and equips with up-conversion luminescence (UCL) nanoparticles as imaging probes, so that the system can generate photothermal and photodynamic effects to treat tumors together with immunotherapy. Especially, the photothermal conversion efficiency can reach 30.84% under the 980 nm laser, which is significantly higher than the conventional Au nanoparticles including nanostars (22.63%) and Au nanorods (23.33%). When the system works in conjunction with immunotherapy, it not only shows a good ability to treat tumors but also can inhibit tumors for a long time and prevent recurrence. Different from the past, in this work, we not only use this strategy to evaluate the performance during the treatment cycle but also observe the mice after the treatment to verify the long-term effect of suppressing tumors. Overall, this study reveals a new inorganic nanosystem and proposes a new strategy for treating tumors in combination with immunotherapy. The present work illustrates the new opportunities for the treatment of primary tumors.
联合多种治疗方法的协同治疗可以有效提高肿瘤治疗效果。光疗和免疫疗法是两种创新且有前途的癌症诊断和治疗方法，因此它们是联合诊断和治疗的良好候选方法。在这里，我们报告了一种新的无机纳米系统，该系统使用超薄黑磷（BP）纳米片（最小：13nm）作为载体，并配备上转换发光（UCL）纳米颗粒作为成像探针，从而使该系统能够与免疫疗法一起产生光热和光动力效应来治疗肿瘤。特别是，该系统在 980nm 激光下的光热转换效率可达到 30.84%，明显高于传统的金纳米颗粒，包括纳米星（22.63%）和金纳米棒（23.33%）。当该系统与免疫疗法联合使用时，它不仅显示出良好的治疗肿瘤能力，而且可以长时间抑制肿瘤并防止复发。与以往不同的是，在这项工作中，我们不仅使用这种策略来评估治疗周期中的性能，还观察治疗后的小鼠，以验证抑制肿瘤的长期效果。总的来说，这项研究揭示了一种新的无机纳米系统，并提出了一种与免疫疗法联合治疗肿瘤的新策略。本工作为原发性肿瘤的治疗提供了新的机会。
