Nagy Ebtesam N, Ali Ahmed Y, Behiry Mervat E, Naguib Mervat M, Elsayed Marwa M
Physical Therapy for Cardiovascular/Respiratory Disorder and Geriatrics Department, Faculty of Physical Therapy, Cairo University, Giza, Egypt.
Internal Medicine Department, Faculty of Medicine, Cairo University, Giza, Egypt.
Int J Gen Med. 2021 Jan 14;14:141-152. doi: 10.2147/IJGM.S280559. eCollection 2021.
Few data are available on the positive impact of photo-biomodulation (PBM) using low-level laser therapy as a complementary treatment for improving the cognitive function and optimizing the hemoglobin (Hb) level and oxygen carrying capacity in anemic elderly patients and consequently improving the quality-of-life. The present study aimed to evaluate a new, safe, and easy therapeutic approach to improve Alzheimer's disease-related symptoms that interfere with the whole life activities and social interaction of elderly patients.
In this placebo-controlled clinical trial, 60 elderly patients suffering from anemia and mild cognitive dysfunction were randomly assigned into two equal groups to receive active or placebo low-level laser in addition to a moderate-intensity aerobic exercise over a 12-week period. Hb level as well as cognitive and functional tests were reassessed for any change after 12 weeks of intervention.
By the end of this study, both groups showed significant improvements in Hb level, Montreal Cognitive Assessment Scale (MoCa - B basic), Quality-of-Life for Alzheimer's Disease scale, and Berg Balance scale scores along with significant reduction in body mass index (BMI) and waist-hip ratio (WHR) (<0.0001). The experimental group which received active low-level laser in addition to moderate-intensity aerobic exercise showed more significant results compared to the control group which received placebo low-level laser in addition to moderate-intensity aerobic exercise in all the measured outcomes (<0.001).
Combined low-level laser therapy and moderate-intensity aerobic exercises are more effective in improving the cognitive function and quality-of-life of Alzheimer's disease patients.
www.ClinicalTrials.gov, identifier NCT04496778.
关于使用低强度激光疗法进行光生物调节（PBM）作为辅助治疗以改善贫血老年患者的认知功能、优化血红蛋白（Hb）水平和氧携带能力从而提高生活质量的积极影响，目前可用数据较少。本研究旨在评估一种新的、安全且简便的治疗方法，以改善干扰老年患者整体生活活动和社交互动的阿尔茨海默病相关症状。
在这项安慰剂对照临床试验中，60名患有贫血和轻度认知功能障碍的老年患者被随机分为两组，在为期12周的时间里，除了进行中等强度有氧运动外，分别接受活性或安慰剂低强度激光治疗。干预12周后，重新评估Hb水平以及认知和功能测试的任何变化。
在本研究结束时，两组患者的Hb水平、蒙特利尔认知评估量表（MoCa - B基础版）、阿尔茨海默病生活质量量表和伯格平衡量表评分均有显著改善，同时体重指数（BMI）和腰臀比（WHR）显著降低（<0.0001）。与接受安慰剂低强度激光加中等强度有氧运动的对照组相比，接受活性低强度激光加中等强度有氧运动的实验组在所有测量结果方面均显示出更显著的效果（<0.001）。
低强度激光疗法与中等强度有氧运动相结合在改善阿尔茨海默病患者的认知功能和生活质量方面更有效。
