Medizinische Klinik I, Universitätsklinik Marien Hospital Herne, Ruhr-Universität Bochum, Germany, Hölkeskampring.
Faculty of Health Sciences Brandenburg, Brandenburg Medical School, Brandenburg.
J Hypertens. 2021 Jul 1;39(7):1269-1273. doi: 10.1097/HJH.0000000000002774.
Blood pressure variability and central SBP are independent markers of cardiovascular risk. Data on lifestyle-interventions to reduce these parameters are sparse. The present work reports the differential effects of aerobic vs. isometric handgrip exercise on blood pressure variability and central SBP in a prospective randomized trial.
Seventy-five hypertensive patients were randomized to one of the following 12-week programs: isometric handgrip training five times weekly; 'Sham-handgrip training' five times weekly; aerobic exercise training (30 min three to five times/week). Blood pressure variability was assessed by the coefficient of variation in 24-h ambulatory blood pressure monitoring (ABPM). Central SBP was measured noninvasively by the SphygmoCor device (AtCor Medical, Australia).
The aerobic exercise program significantly decreased systolic daytime variability (12.1 ± 2.5 vs. 10.3 ± 2.8, P = 0.04), whereas diastolic daytime blood pressure variability was not significantly altered (P = 0.14). Night-time variability was not significantly affected (P > 0.05). Central SBP was reduced from 145±15 to 134 ± 19 mmHg (P = 0.01). Isometric handgrip and sham-handgrip exercise did not significantly affect blood pressure variability (P > 0.05 each). Isometric exercise tended to reduce central SBP (142 ± 19 to 136 ± 17 mmHg, P = 0.06). ANCOVA revealed significant intergroup differences for the change of daytime SBP and DBP variability (P = 0.048 and 0.047, respectively).
Aerobic exercise reduces blood pressure variability and central SBP. Isometric handgrip exercise does not reduce blood pressure variability but tends to lower central SBP in this hypertensive population.
血压变异性和中心收缩压是心血管风险的独立标志物。关于降低这些参数的生活方式干预的数据很少。本研究报告了在一项前瞻性随机试验中，有氧运动与等长握力运动对血压变异性和中心收缩压的差异影响。
75 名高血压患者被随机分为以下 12 周方案之一：等长握力训练每周 5 次；“假手握训练”每周 5 次；有氧运动训练（每周 3-5 次，每次 30 分钟）。通过 24 小时动态血压监测（ABPM）的变异系数评估血压变异性。通过 SphygmoCor 设备（澳大利亚 AtCor Medical）无创测量中心收缩压。
有氧运动方案显著降低了收缩压日间变异性（12.1±2.5 对 10.3±2.8，P=0.04），而舒张压日间血压变异性无明显变化（P=0.14）。夜间变异性无明显影响（P>0.05）。中心收缩压从 145±15 降至 134±19 mmHg（P=0.01）。等长握力和假手握力运动对血压变异性没有显著影响（P>0.05 各）。等长运动倾向于降低中心收缩压（从 142±19 降至 136±17 mmHg，P=0.06）。协方差分析显示日间收缩压和舒张压变异性的组间差异有统计学意义（P=0.048 和 0.047）。
有氧运动可降低血压变异性和中心收缩压。等长握力运动不能降低血压变异性，但在该高血压人群中倾向于降低中心收缩压。
