Laboratory of Biotechnology, Environment, Agrifood, and Health, University of Sidi Mohamed Ben Abdellah, FSDM-Fez 47963, Morocco.
Basic Science Department, College of Medicine, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia.
Molecules. 2021 Jan 18;26(2):487. doi: 10.3390/molecules26020487.
L. seeds are traditionally used to treat diabetes and its complications (inflammation and formation of reactive oxygen species) around the world. The present study investigates the antidiabetic, anti-inflammatory, and antioxidant effects of the polyphenol fraction of seeds (PCS). Diabetic mice were orally administered with PCS (25 and 50 mg/kg b.w.) for 28 days. Oral glucose tolerance (OGTT) was also evaluated along with the anti-inflammatory effect, assessed by measuring paw edema development induced with carrageenan in Wistar rat and the antioxidant activity assessed using two tests (β-carotene discoloration and DPPH). Treatment of diabetic mice with PCS for four weeks managed their high fasting blood glucose levels, improved their overall health, also revealed an excellent antihyperlipidemic activity. The OGTT result showed a potent antihyperglycemic activity, and following the anti-inflammatory and antioxidant effects, the PCS exhibited a perfect activity. LC-MS/MS result revealed the presence of 9 polyphenols. This modest work indicates that the PCS have an important antidiabetic, antihyperglycemic, antihyperlipidemic, anti-inflammatory, and antioxidant effect that can be well established treatment of diabetes and its complications.
L. 种子在世界各地被传统用于治疗糖尿病及其并发症（炎症和活性氧形成）。本研究调查了 L. 种子多酚部分（PCS）的抗糖尿病、抗炎和抗氧化作用。糖尿病小鼠经口给予 PCS（25 和 50mg/kg b.w.）28 天。还评估了口服葡萄糖耐量（OGTT），以及通过测量角叉菜胶诱导的 Wistar 大鼠爪肿胀发展来评估抗炎作用，以及使用两种测试（β-胡萝卜素褪色和 DPPH）评估抗氧化活性。用 PCS 治疗糖尿病小鼠四周可控制其高空腹血糖水平，改善其整体健康状况，还显示出良好的抗高血脂活性。OGTT 结果显示出很强的降血糖活性，抗炎和抗氧化作用后，PCS 表现出极好的活性。LC-MS/MS 结果显示存在 9 种多酚。这项适度的工作表明，PCS 具有重要的抗糖尿病、降血糖、抗高血脂、抗炎和抗氧化作用，可作为糖尿病及其并发症的有效治疗方法。
