NHC Key Laboratory of Systems Biology of Pathogens, Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Key Laboratory of Respiratory Disease Pathogenomics, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
Microbiome. 2021 Jan 21;9(1):18. doi: 10.1186/s40168-020-00965-z.
As the largest group of mammalian species, which are also widely distributed all over the world, rodents are the natural reservoirs for many diverse zoonotic viruses. A comprehensive understanding of the core virome of diverse rodents should therefore assist in efforts to reduce the risk of future emergence or re-emergence of rodent-borne zoonotic pathogens.
This study aimed to describe the viral range that could be detected in the lungs of rodents from Mainland Southeast Asia. Lung samples were collected from 3284 rodents and insectivores of the orders Rodentia, Scandentia, and Eulipotyphla in eighteen provinces of Thailand, Lao PDR, and Cambodia throughout 2006-2018. Meta-transcriptomic analysis was used to outline the unique spectral characteristics of the mammalian viruses within these lungs and the ecological and genetic imprints of the novel viruses. Many mammalian- or arthropod-related viruses from distinct evolutionary lineages were reported for the first time in these species, and viruses related to known pathogens were characterized for their genomic and evolutionary characteristics, host species, and locations.
These results expand our understanding of the core viromes of rodents and insectivores from Mainland Southeast Asia and suggest that a high diversity of viruses remains to be found in rodent species of this area. These findings, combined with our previous virome data from China, increase our knowledge of the viral community in wildlife and arthropod vectors in emerging disease hotspots of East and Southeast Asia. Video abstract.
作为最大的哺乳动物物种群体，它们也广泛分布于世界各地，啮齿动物是许多不同的人畜共患病病毒的天然宿主。因此，全面了解不同啮齿动物的核心病毒组有助于降低未来啮齿动物传播的人畜共患病病原体出现或再现的风险。
本研究旨在描述可从东南亚大陆的啮齿动物肺部中检测到的病毒范围。2006 年至 2018 年，从泰国、老挝和柬埔寨的 18 个省的啮齿目、攀禽目和食虫目 3284 只啮齿动物和食虫动物中采集了肺样本。采用元转录组学分析方法，概述了这些肺部中哺乳动物病毒的独特光谱特征，以及新型病毒的生态和遗传印记。首次在这些物种中报告了来自不同进化谱系的许多哺乳动物或节肢动物相关病毒，并且对与已知病原体相关的病毒进行了基因组和进化特征、宿主物种和位置的特征描述。
这些结果扩展了我们对东南亚大陆啮齿动物和食虫动物核心病毒组的认识，并表明该地区啮齿动物物种中仍存在高度多样化的病毒。这些发现，结合我们之前在中国的病毒组数据，增加了我们对东亚和东南亚新兴疾病热点地区野生动物和节肢动物媒介病毒群的了解。视频摘要。
