Department of Physiology, University of Louisville School of Medicine, Louisville, KY, 40202, USA.
Mol Cell Biochem. 2021 Apr;476(4):1891-1895. doi: 10.1007/s11010-021-04054-z. Epub 2021 Jan 22.
Corona virus disease-19 (covid-19) is caused by a coronavirus that is also known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and is generally characterized by fever, respiratory inflammation, and multi-organ failure in susceptible hosts. One of the first things during inflammation is the response by acute phase proteins coupled with coagulation. The angiotensinogen (a substrate for hypertension) is one such acute phase protein and goes on to explain an association of covid-19 with that of angiotensin-converting enzyme-2 (ACE2, a metallopeptidase). Therefore, it is advisable to administer, and test the efficacy of specific blocker(s) of angiotensinogen such as siRNAs or antibodies to covid-19 subjects. Covid-19 activates neutrophils, macrophages, but decreases T-helper cells activity. The metalloproteinases promote the activation of these inflammatory immune cells, therefore; we surmise that doxycycline (a metalloproteinase inhibitor, and a safer antibiotic) would benefit the covid-19 subjects. Along these lines, an anti-acid has also been suggested for mitigation of the covid-19 complications. Interestingly, there are three primary vegetables (celery, carrot, and long-squash) which are alkaline in their pH-range as compared to many others. Hence, treatment with fresh juice (without any preservative) from these vegies or the antioxidants derived from purple carrot and cabbage together with appropriate anti-coagulants may also help prevent or lessen the detrimental effects of the covid-19 pathological outcomes. These suggested remedies might be included in the list of putative interventions that are currently being investigated towards mitigating the multi-organ damage by Covid-19 during the ongoing pandemic.
新型冠状病毒病（COVID-19）是由一种冠状病毒引起的，这种冠状病毒也被称为严重急性呼吸系统综合征冠状病毒 2（SARS-CoV-2），通常以易感宿主的发热、呼吸道炎症和多器官衰竭为特征。炎症发生的早期反应之一是急性相蛋白与凝血的结合。血管紧张素原（高血压的底物）就是这样一种急性相蛋白，它进一步解释了 COVID-19 与血管紧张素转换酶 2（ACE2，一种金属肽酶）之间的关联。因此，给 COVID-19 患者服用和测试血管紧张素原的特定抑制剂（如 siRNA 或抗体）的疗效是明智的。COVID-19 会激活中性粒细胞、巨噬细胞，但会降低 T 辅助细胞的活性。金属蛋白酶促进这些炎症免疫细胞的激活，因此，我们推测多西环素（一种金属蛋白酶抑制剂，也是一种更安全的抗生素）将有益于 COVID-19 患者。沿着这些思路，也有人建议使用抗酸剂来缓解 COVID-19 的并发症。有趣的是，有三种主要的蔬菜（芹菜、胡萝卜和长南瓜）在其 pH 值范围内呈碱性，而其他许多蔬菜则呈酸性。因此，用这些蔬菜的新鲜汁（不含任何防腐剂）或从紫胡萝卜和卷心菜中提取的抗氧化剂，以及适当的抗凝剂进行治疗，也可能有助于预防或减轻 COVID-19 病理结果的有害影响。这些建议的治疗方法可能会被列入目前正在研究的减轻 COVID-19 在大流行期间对多器官损害的潜在干预措施清单中。
