State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, 530004, Guangxi, China.
Mol Cell Biochem. 2021 Apr;476(4):1897-1903. doi: 10.1007/s11010-021-04057-w. Epub 2021 Jan 24.
Lipid accumulation in mammals has been widely studied for decades due to its significant association with obesity in humans and meat quality in livestock animals. Fatty acid transport 1 (FATP1) is an evolutionarily conserved protein that localizes to the plasma membrane to enhance the transportation of fatty acids (FAs). In line with this function, FATP1 is involved in the metabolism of FAs, including their esterification and oxidation. In addition, the expression of FATP1 can be regulated by several energy-related factors, such as insulin and PPAR activators and transcription factors. These events connect FATP1 with cellular lipid accumulation. Recently, several studies have suggested that FATP1 acts as a facilitator in cellular lipid accumulation, whereas others hold a contrary view. Here, we will review these data and probe the possibility that FATP1 acts as a regulator in lipid accumulation, which will provide effective information for studies on the relationship between FATP1 and obesity in humans and meat quality in livestock animals.
几十年来，由于脂肪在哺乳动物中的积累与人类肥胖和家畜肉质密切相关，因此受到了广泛的研究。脂肪酸转运蛋白 1（FATP1）是一种进化上保守的蛋白质，它定位于质膜以增强脂肪酸（FAs）的运输。根据这一功能，FATP1 参与了 FAs 的代谢，包括它们的酯化和氧化。此外，FATP1 的表达可以受到几种与能量相关的因素的调节，如胰岛素和 PPAR 激活剂和转录因子。这些事件将 FATP1 与细胞内脂质积累联系起来。最近，有几项研究表明 FATP1 作为细胞内脂质积累的促进剂发挥作用，而另一些研究则持相反观点。在这里，我们将回顾这些数据，并探讨 FATP1 是否作为脂质积累的调节剂发挥作用的可能性，这将为研究 FATP1 与人类肥胖和家畜肉质的关系提供有效的信息。
