Department of Dermatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
College of Medicine, Chang Gung University, Taoyuan, Taiwan.
Adv Ther. 2021 Mar;38(3):1415-1424. doi: 10.1007/s12325-021-01624-x. Epub 2021 Jan 28.
Rosacea is a chronic inflammatory disease with complicated pathophysiology that involves genetic and environmental elements and dysregulation of innate and adaptive immunity, neurovascular responses, microbiome colonization or infection, resulting in recurrent inflammation. Rosacea has been reported associated with various gastrointestinal diseases including inflammatory bowel disease, celiac disease, irritable bowel syndrome, gastroesophageal reflux disease, Helicobacter pylori (HP) infection, and small intestine bacterial overgrowth (SIBO). The link may involve common predisposing genetic, microbiota, and immunological factors, comprising the theory of the gut-skin axis. Although the evidence is still controversial, interestingly, medications for eradicating SIBO and HP provided an effective and prolonged therapeutic response in rosacea, and conventional therapy for which is usually disappointing because of frequent relapses. In this article, we review the current evidence and discuss probable mechanisms of the association between rosacea and gastrointestinal comorbidities.
酒渣鼻是一种慢性炎症性疾病，其发病机制复杂，涉及遗传和环境因素以及固有和适应性免疫、神经血管反应、微生物组定植或感染的失调，导致反复炎症。酒渣鼻与各种胃肠道疾病有关，包括炎症性肠病、乳糜泻、肠易激综合征、胃食管反流病、幽门螺杆菌（HP）感染和小肠细菌过度生长（SIBO）。这种联系可能涉及共同的易患遗传、微生物组和免疫因素，构成了肠道-皮肤轴的理论。尽管证据仍存在争议，但有趣的是，消除 SIBO 和 HP 的药物在酒渣鼻中提供了有效和持久的治疗反应，而常规治疗通常令人失望，因为经常复发。在本文中，我们回顾了目前的证据，并讨论了酒渣鼻与胃肠道合并症之间关联的可能机制。
