Caffarel-Salvador Ester, Kim Soyoung, Soares Vance, Tian Ryan Yu, Stern Sarah R, Minahan Daniel, Yona Raissa, Lu Xiaoya, Zakaria Fauziah R, Collins Joy, Wainer Jacob, Wong Jessica, McManus Rebecca, Tamang Siddartha, McDonnell Shane, Ishida Keiko, Hayward Alison, Liu Xiewen, Hubálek František, Fels Johannes, Vegge Andreas, Frederiksen Morten Revsgaard, Rahbek Ulrik, Yoshitake Tadayuki, Fujimoto James, Roxhed Niclas, Langer Robert, Traverso Giovanni
Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Department of Chemical Engineering and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Sci Adv. 2021 Jan 22;7(4). doi: 10.1126/sciadv.abe2620. Print 2021 Jan.
Alternative means for drug delivery are needed to facilitate drug adherence and administration. Microneedles (MNs) have been previously investigated transdermally for drug delivery. To date, drug loading into MNs has been limited by drug solubility in the polymeric blend. We designed a highly drug-loaded MN patch to deliver macromolecules and applied it to the buccal area, which allows for faster delivery than the skin. We successfully delivered 1-mg payloads of human insulin and human growth hormone to the buccal cavity of swine within 30 s. In addition, we conducted a trial in 100 healthy volunteers to assess potential discomfort associated with MNs when applied in the oral cavity, identifying the hard palate as the preferred application site. We envisage that MN patches applied on buccal surfaces could increase medication adherence and facilitate the painless delivery of biologics and other drugs to many, especially for the pediatric and elderly populations.
需要其他给药方式来促进药物依从性和给药。微针（MNs）此前已被研究用于经皮给药。迄今为止，药物载入微针受到药物在聚合物共混物中溶解度的限制。我们设计了一种高载药量的微针贴片来递送大分子，并将其应用于颊部区域，该区域比皮肤能实现更快的递送。我们成功在30秒内将1毫克的人胰岛素和人生长激素有效载荷递送至猪的颊腔。此外，我们对100名健康志愿者进行了一项试验，以评估微针应用于口腔时可能产生的不适，确定硬腭为首选应用部位。我们设想，应用于颊部表面的微针贴片可以提高药物依从性，并促进生物制剂和其他药物无痛递送给许多人，尤其是儿童和老年人群体。
