Department of Geriatrics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.
Department of Orthopedics, Xijing Hospital, the Fourth Military Medical University, Xi'an, China.
Colloids Surf B Biointerfaces. 2021 Apr;200:111588. doi: 10.1016/j.colsurfb.2021.111588. Epub 2021 Jan 22.
Infections resulting from bacteria and biofilms have become a huge problem threatening human health. In recent years, the antibacterial and antibiofilm effects of graphene and its derivatives have been extensively studied. However, there continues to be some controversy over whether graphene and its derivatives can resist infection and biofilms. Moreover, the antibacterial mechanism and cytotoxicity of graphene and its derivatives are unclear. In the present review, antibacterial and antibiofilm abilities of graphene and its derivatives in solution, on the surface are reviewed, and their toxicity and possible mechanisms are also reviewed. Furthermore, we propose possible future development directions for graphene and its derivatives in antibacterial and antibiofilm applications.
由细菌和生物膜引起的感染已经成为威胁人类健康的一个大问题。近年来,石墨烯及其衍生物的抗菌和抗生物膜作用得到了广泛的研究。然而,关于石墨烯及其衍生物是否能抵抗感染和生物膜仍然存在一些争议。此外,石墨烯及其衍生物的抗菌机制和细胞毒性尚不清楚。在本综述中,我们综述了石墨烯及其衍生物在溶液中和表面上的抗菌和抗生物膜能力,以及它们的毒性和可能的作用机制。此外,我们还提出了石墨烯及其衍生物在抗菌和抗生物膜应用中可能的未来发展方向。