Faculty of Medicine, Damascus University, Damascus, Syria.
Sci Rep. 2021 Feb 3;11(1):2870. doi: 10.1038/s41598-020-80793-1.
Allergic rhinitis (AR) is a common medical condition worldwide. It is an inflammation in the nasal mucosa due to allergen exposure throughout the year. Laryngopharyngeal reflux (LPR) is another medical condition that can overlap with AR. LPR can be considered an extra oesophageal manifestation of gastro-oesophageal reflux disease (GORD) or a different entity. Its diagnosis imposes a real challenge as it has a wide range of unspecific symptoms. Although AR and LPR are not life-threatening, they can severely affect the quality of life for years and cause substantial distress. Moreover, having AR is associated with having asthma which is also in turn associated with GORD. This is a cross-sectional study which used surveys distributed online on Social Media and targeted people across Syria. All participants who responded to the key questions were included. Reflux symptom index (RSI) was used for LPR, and score for allergic rhinitis (SFAR) was used for AR. Demographic questions and whether the participant had asthma were also included in the survey. We found that there was an association between the symptoms of LPR and AR p < 0.0001 (OR, 2.592; 95% CI 1.846-3.639), and their scores were significantly correlated (r = 0.334). Having asthma was associated with LPR symptoms p = 0.0002 (OR 3.096; 95% CI 1.665-5.759) and AR p < 0.0001 (OR 6.772; 95% CI 2.823-16.248). We concluded that there was a significant association between having LPR, AR, and asthma. We need more studies to distinguish between their common symptoms and aetiologies.
变应性鼻炎（AR）是一种常见的全球医学病症。它是由于全年过敏原暴露引起的鼻黏膜炎症。喉咽反流（LPR）是另一种与 AR 重叠的医学病症。LPR 可以被认为是胃食管反流病（GORD）的一种食管外表现，也可以被视为一种不同的实体。其诊断具有挑战性，因为它有广泛的非特异性症状。尽管 AR 和 LPR 不会危及生命，但它们会在多年内严重影响生活质量并引起极大的不适。此外，患有 AR 与患有哮喘有关，而哮喘又与 GORD 有关。这是一项横断面研究，使用在线社交媒体上分发的调查，针对叙利亚各地的人群。所有回答关键问题的参与者都被包括在内。反流症状指数（RSI）用于 LPR，过敏评分（SFAR）用于 AR。调查还包括人口统计学问题和参与者是否患有哮喘。我们发现，LPR 和 AR 的症状之间存在关联（p<0.0001，OR，2.592；95%CI，1.846-3.639），并且它们的评分呈显著相关性（r=0.334）。患有哮喘与 LPR 症状相关（p=0.0002，OR，3.096；95%CI，1.665-5.759）和 AR 相关（p<0.0001，OR，6.772；95%CI，2.823-16.248）。我们得出结论，LPR、AR 和哮喘之间存在显著关联。我们需要更多的研究来区分它们的常见症状和病因。
