Department of Pediatrics, IRCCS Giannina Gaslini Institute, 16147 Genova, Italy.
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics, Child and Maternal Health, University of Genova, 16132 Genova, Italy.
Nutrients. 2021 Feb 2;13(2):485. doi: 10.3390/nu13020485.
We aimed to assess Health-Related Quality of Life (HRQoL) of Italian children and their parents with coeliac disease (CD) using the Coeliac Disease Dutch Questionnaire (CDDUX). The CDDUX underwent a cross-cultural adaptation in a multi-step process, according to international guidelines. A total of 224 children aged between 8-18 years and their parents were prospectively recruited. Cronbach α coefficient was determined as a measure of internal consistency of the questionnaire and inter-children/parent reliability by intraclass correlation coefficient. Univariate and bivariate regression models were used to evaluate correlations between clinical variables and children and parents subclasses of CDDUX and overall mean Paediatric Quality of Life Inventory (PedsQL). The Italian CDDUX proved to be valid and reliable, mean CDDUX total score revealing a neutral evaluation of the quality of life in children 52.6 ± 17.2 and parents 49.5 ± 17.9 ( = 0.07) with strong correlation with PedsQL. The only clinical variable which appeared to affect significantly quality of life both in children and parents was the lower age. A comparison with our results showed remarkable differences in the HRQoL of populations of various nationalities. The Italian version of the CDDUX questionnaire is a simple and reliable tool for assessing the HRQoL in children and adolescents with CD.
我们旨在使用乳糜泻荷兰问卷 (CDDUX) 评估意大利患有乳糜泻的儿童及其父母的健康相关生活质量 (HRQoL)。根据国际指南，CDDUX 经过多步骤的跨文化适应性调整。总共前瞻性招募了 224 名年龄在 8-18 岁之间的儿童及其父母。Cronbach α 系数用于确定问卷的内部一致性，并通过组内相关系数评估儿童和父母之间的可靠性。单变量和双变量回归模型用于评估临床变量与儿童和父母的 CDDUX 子类和整体儿童生活质量量表 (PedsQL) 之间的相关性。意大利 CDDUX 被证明是有效且可靠的，CDDUX 总得分平均值为 52.6 ± 17.2，表明儿童的生活质量处于中性水平，父母的生活质量为 49.5 ± 17.9（ = 0.07），与 PedsQL 具有很强的相关性。唯一似乎显著影响儿童和父母生活质量的临床变量是较低的年龄。与我们的结果进行比较显示，不同国籍人群的 HRQoL 存在显著差异。意大利版 CDDUX 问卷是评估乳糜泻儿童和青少年 HRQoL 的简单可靠工具。
