噪声暴露对高血压发病风险的影响：队列研究的系统评价和荟萃分析。
Impact of exposure to noise on the risk of hypertension: A systematic review and meta-analysis of cohort studies.
机构信息
School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Hubei, China.
School of Nursing, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.
出版信息
Environ Res. 2021 Apr;195:110813. doi: 10.1016/j.envres.2021.110813. Epub 2021 Feb 2.
OBJECTIVE
We aimed to synthesize available cohorts about the relationship between various types of noise and hypertension, and to explore the potential dose-response relationship between them in an updated meta-analysis.
METHODS
PubMed and Embase were searched through October 2019 to identify cohort studies that met predetermined inclusion criteria. A random-effects model was used to combine the results of included studies. Dose-response meta-analysis was conducted to examine the potential dose-response relationship.
RESULTS
Eleven cohort studies involving 224,829 participants were included in this systematic review. Pooled result showed that living or working in environment with noise exposure was significantly associated with increased risk of hypertension (RR: 1.18; 95% CI: 1.06 to 1.32), with low heterogeneity (P = 0.098, I = 42.1%). We found no evidence of a nonlinear association of elevated noise with hypertension risk (P = 0.443). The summary risk ratio of hypertension for an increment of per 10 dB(A) of noise was 1.13 (95% CI: 0.99 to 1.28), with moderate heterogeneity (P = 0.003, I = 72.1%).
CONCLUSIONS
Integrated evidence from cohort studies supports the hypothesis that exposure to noise may be a risk factor of hypertension.
目的
本研究旨在综合分析各种类型噪声与高血压之间关系的现有队列研究，并通过更新的荟萃分析探讨它们之间潜在的剂量-反应关系。
方法
通过检索 PubMed 和 Embase，我们纳入了截至 2019 年 10 月符合预先设定纳入标准的队列研究。使用随机效应模型对纳入研究的结果进行合并。我们进行了剂量-反应荟萃分析，以评估潜在的剂量-反应关系。
结果
本系统评价共纳入了 11 项队列研究，涉及 224829 名参与者。汇总结果显示，生活或工作在噪声暴露环境中与高血压风险增加显著相关（RR：1.18；95% CI：1.06 至 1.32），异质性较低（P=0.098，I²=42.1%）。我们未发现噪声升高与高血压风险之间存在非线性关联的证据（P=0.443）。噪声每增加 10dB(A)，高血压风险的汇总风险比为 1.13（95% CI：0.99 至 1.28），异质性中等（P=0.003，I²=72.1%）。
结论
来自队列研究的综合证据支持噪声暴露可能是高血压的一个危险因素的假说。
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