Kimura Takeshi, Araki Takashi, Komuku Yuki, Iwami Hisashi, Gomi Fumi
Department of Ophthalmology, Hyogo College of Medicine, Nishinomiya 6638501, Japan.
J Clin Med. 2021 Feb 3;10(4):558. doi: 10.3390/jcm10040558.
To investigate blood serotonin (5-hydroxytryptamine (5-HT)) concentrations and their relationships with selected characteristics in patients with central serous chorioretinopathy (CSC).
This was a prospective study including 93 patients with active CSC. Blood concentrations of 5-HT, adrenocorticotropic hormone, and cortisol were measured in patients with CSC. Selected patient characteristics, including disease history (acute or chronic), medication use, smoking history, mood status, best-corrected visual acuity (BCVA), subfoveal choroidal thickness (SCT), findings on fluorescein and indocyanine green angiography, and anatomical changes were evaluated during follow-up.
Eleven of the 93 patients had low 5-HT concentrations (<57 ng/mL) (12%, eight men and three women; mean age 55 years); we identified no significant relationship with acute/chronic disease status. The patients with low 5-HT were significantly more likely to have five or more fluorescein leakage sites ( = 0.0275), recurrence of subretinal fluids ( < 0.0001), and failure to achieve significant improvement in BCVA during follow-up ( = 0.862) than patients with 5-HT within the normal range.
Blood serotonin concentrations may influence the pathophysiology and prognosis of CSC.
研究中心性浆液性脉络膜视网膜病变（CSC）患者的血液血清素（5-羟色胺（5-HT））浓度及其与特定特征的关系。
这是一项前瞻性研究，纳入93例活动性CSC患者。检测CSC患者血液中5-HT、促肾上腺皮质激素和皮质醇的浓度。在随访期间评估选定的患者特征，包括病史（急性或慢性）、用药情况、吸烟史、情绪状态、最佳矫正视力（BCVA）、黄斑下脉络膜厚度（SCT）、荧光素和吲哚菁绿血管造影结果以及解剖学变化。
93例患者中有11例5-HT浓度较低（<57 ng/mL）（12%，8名男性和3名女性；平均年龄55岁）；我们未发现其与急性/慢性疾病状态有显著关系。与5-HT浓度在正常范围内的患者相比，5-HT浓度低的患者更有可能有五个或更多荧光素渗漏部位（P = 0.0275）、视网膜下液复发（P < 0.0001）以及在随访期间BCVA未实现显著改善（P = 0.862）。
血液血清素浓度可能影响CSC的病理生理学和预后。
