Ethanol extract of L. increases life span in .

The stem of L. (Fabaceae) has been used in traditional Thai medicine as a longevity remedy. The objective of this study was to investigate the effect of ethanolic stem extract of (CSE) on the life span of . The results showed that a diet containing 10 mg/mL CSE could significantly extend the mean life span of by 14% compared with the control diet (P < 0.01). The maximum life span was 74, 78, and 84 days in control, CSE (5 mg/mL) and CSE (10 mg/mL) groups, respectively. Supplementation of CSE at 10 mg/mL also significantly increases the activity of superoxide dismutase (SOD) and catalase (CAT) at days 25 and 40 compared with the control diet. Treatment of CSE at 5 and 10 mg/mL significantly increased the climbing ability of both on days 25 and 40 compared with the control flies. Paraquat and HO challenge test showed that flies fed with CSE at 10 mg/mL had a longer survival time than the control flies ( < 0.01). This study provides supportive evidence that supplementation with CSE prolonged life span and reduced oxidative stress in .