Department of Brain and Cognitive Sciences, Daegu Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Korea.
STAR Protoc. 2021 Jan 30;2(1):100305. doi: 10.1016/j.xpro.2021.100305. eCollection 2021 Mar 19.
Social cooperation in rodents was recently validated in rats, and we recently successfully applied a modified automated analysis to mice. Here, we describe a detailed procedure for using this paradigm in mice that relies on reward-based mutual communication that is automatically detected by a software algorithm embedded in the custom-made equipment. We also describe exemplary results of analyses in mice as a guide to broader neuroscience research applications employing transgenic knockout mice modeling neuropsychiatric disorders and mice of various ages. For complete details on the use and execution of this protocol, please refer to Han et al. (2020).
最近，啮齿动物的社会合作在大鼠中得到了验证，我们最近成功地将一种改良的自动分析应用于小鼠。在这里，我们描述了一种在小鼠中使用该范式的详细程序，该程序依赖于基于奖励的相互通信，由嵌入在定制设备中的软件算法自动检测。我们还描述了在小鼠中分析的示例结果，以指导更广泛的神经科学研究应用，包括使用建模神经精神障碍的转基因敲除小鼠和各种年龄的小鼠。有关使用和执行此方案的完整详细信息，请参见 Han 等人。(2020)。
