Department of Basic Sciences, Neuroscience and Sense Organs, Aldo Moro University of Bari, Italy.
Department of Biomedical Science and Human Oncology, Aldo Moro University of Bari, Italy.
Endocr Metab Immune Disord Drug Targets. 2022;22(1):108-115. doi: 10.2174/1871530321666210210153619.
Low back pain (LBP) is a frequent symptom. Among the causes that can determine it, lumbar osteoarthritis plays an important role. Therapeutic exercise, according to McKenzie method, has been shown to be effective in the treatment of LBP. Oral supplementation with collagen peptides represents a new therapeutic possibility in osteoarthritis. The aim of this study is to evaluate the combined efficacy of therapeutic exercise and oral administered viscosupplements in the treatment of osteoarthritis-related chronic LBP.
Sixty patients were recruited and randomly divided into two groups (Group A and B). Group A performed only kinesitherapy, Group B carried out the same kinesitherapy combined with the daily administration of food supplements such as Fortigel®, Vitamin C, sodium hyaluronate, manganese and copper, during the whole treatment period. Patients were evaluated at the time of recruitment (T0), at the end of the treatment (T1 - 3 weeks after T0) and 6 weeks after T1 (T2). The outcome measures used were: Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and Short Form-12 (SF-12).
All the outcomes improved significantly at T1 in both groups, but more markedly in group B. Furthermore, in group A at T2, there was a statistically significant worsening in the scores of VAS, ODI and physical component of the SF-12, while in group B, this variation has not been detected.
The combination of rehabilitation based on McKenzie back exercises and oral viscosupplementation with Fortigel®, Vitamin C, sodium hyaluronate, manganese and copper represents a valid option in patients with chronic LBP, as it ensures pain relief and improvement in the quality of life and in lumbar spine functionality. These therapeutic benefits are more evident and long-lasting compared to those obtained with rehabilitation alone.
腰痛（LBP）是一种常见的症状。在导致腰痛的诸多原因中，腰椎骨关节炎起着重要作用。根据麦肯基疗法进行的治疗性运动已被证明对腰痛的治疗有效。口服胶原肽补充剂是治疗骨关节炎的一种新的治疗可能性。本研究旨在评估治疗性运动和口服关节内补充剂联合治疗与骨关节炎相关的慢性腰痛的综合疗效。
招募了 60 名患者，并将其随机分为两组（A 组和 B 组）。A 组仅进行运动疗法，B 组在整个治疗期间同时进行相同的运动疗法，并每日服用关节内补充剂，如 Fortigel®、维生素 C、透明质酸钠、锰和铜。患者在招募时（T0）、治疗结束时（T1-在 T0 后 3 周）和 T1 后 6 周（T2）进行评估。使用的结局指标为：视觉模拟评分（VAS）、Oswestry 残疾指数（ODI）和简明健康调查问卷 12 项（SF-12）。
两组在 T1 时所有结局均显著改善，但 B 组改善更为明显。此外，在 A 组 T2 时，VAS、ODI 和 SF-12 身体成分评分有统计学显著恶化，而在 B 组未发现这种变化。
基于麦肯基背部运动的康复与口服 Fortigel®、维生素 C、透明质酸钠、锰和铜联合关节内补充治疗，是慢性腰痛患者的有效选择，因为它可以缓解疼痛，提高生活质量和腰椎功能。与单独康复相比，这些治疗益处更为明显且持久。
