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诊断烧伤创面感染:实践差距与MolecuLight细菌成像技术的进展

Diagnosing Burn Wounds Infection: The Practice Gap & Advances with MolecuLight Bacterial Imaging.

作者信息

Farhan Nawras, Jeffery Steven

机构信息

Burn Centre, Birmingham Women's and Children's NHS Foundation Trust, Birmingham B4 6NH, UK.

Wound Healing Practice Development Unit, Birmingham City University, Birmingham B15 3TN, UK.

出版信息

Diagnostics (Basel). 2021 Feb 9;11(2):268. doi: 10.3390/diagnostics11020268.

DOI:10.3390/diagnostics11020268
PMID:33572369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7916143/
Abstract

Burn injuries constitute a critical economic burden on healthcare infrastructures worldwide. They are often associated with high mortality rates due to severe complications. Infection is the most common complication, highlighting the importance of prompt and precise diagnosis in order to prevent detrimental consequences and to optimize patient outcomes. Here we examine the current standard of care for diagnosing infection in both burn and chronic wounds followed by an investigation into the research surrounding a relatively new technique for bacterial detection, fluorescence imaging. With five years of published research on bacterial fluorescence imaging (MolecuLight device), we have summarized and analysed the validity of the procedure and compared it to the current standard of care; clinical assessment and microbiological analysis. We highlight the benefits that could be obtained through the use of this technology as well as the limitations and the feasibility of incorporating this novel procedure into the standard of care.

摘要

烧伤对全球医疗基础设施构成了严重的经济负担。由于严重并发症,烧伤常常伴随着高死亡率。感染是最常见的并发症,这凸显了及时准确诊断的重要性,以便预防不良后果并优化患者预后。在此,我们研究了烧伤和慢性伤口感染诊断的当前护理标准,随后调查了一项相对较新的细菌检测技术——荧光成像的相关研究。基于对细菌荧光成像(MolecuLight设备)五年的已发表研究,我们总结并分析了该程序的有效性,并将其与当前的护理标准——临床评估和微生物分析进行了比较。我们强调了通过使用该技术可能获得的益处,以及将这一新技术纳入护理标准的局限性和可行性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/626fa73d2f34/diagnostics-11-00268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/2ec782200d8c/diagnostics-11-00268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/84296d1be882/diagnostics-11-00268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/08ed2311d3be/diagnostics-11-00268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/626fa73d2f34/diagnostics-11-00268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/2ec782200d8c/diagnostics-11-00268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/84296d1be882/diagnostics-11-00268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/08ed2311d3be/diagnostics-11-00268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8aa7/7916143/626fa73d2f34/diagnostics-11-00268-g004.jpg

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Diabetes Care. 2022 Jul 7;45(7):1601-1609. doi: 10.2337/dc21-2218.
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A Prospective Multisite Observational Study Incorporating Bacterial Fluorescence Information Into the UPPER/LOWER Wound Infection Checklists.一项前瞻性多中心观察性研究,将细菌荧光信息纳入 UPPER/LOWER 伤口感染清单。
Wounds. 2020 Nov;32(11):299-308.
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BMC Microbiol. 2025 Aug 15;25(1):511. doi: 10.1186/s12866-025-04200-3.
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Prospective evaluation of the Moleculight i:X™ in the early detection of driveline infections.Moleculight i:X™在早期检测动静脉感染中的前瞻性评估。
Interdiscip Cardiovasc Thorac Surg. 2025 Mar 29;40(4). doi: 10.1093/icvts/ivae215.
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Bacteriophage therapy reduces in a porcine and human burn wound infection model.噬菌体疗法可减少猪与人烧伤感染模型中的 。
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