Weber J P
Centre de Toxicologie du Québec, Sainte-Foy, Canada.
Sci Total Environ. 1988 Apr;71(1):111-23. doi: 10.1016/0048-9697(88)90305-1.
Since 1979, the Centre de Toxicologie du Québec has operated an interlaboratory comparison programme for several toxic substances in blood and urine. We initiated this program due to the unavailability of reliable and representative reference materials for toxic elements in blood and urine. The main objective is to enable participants to improve or maintain the accuracy of their analytical work by periodically comparing their results. There are presently 76 laboratories registered in the programme for one or more substances. The majority are located in North America with several others in Europe and South America. Available substances include lead and cadmium in blood, aluminum in serum, and mercury, arsenic, cadmium, fluoride and chromium in urine. Samples are prepared by pooling specimens obtained from exposed workers. We have examined the performance of participants over the course of the years using as criteria the deviation from the target value, the scatter of results and the proficiency within preset limits of toxicological significance. Whenever possible the influence of analytical methods was evaluated. The feedback provided by participation in the programme appears to be a significant factor in the maintenance or improvement of analytical proficiency. The vast majority of participants obtain results of adequate reliability for use in the monitoring of exposed workers.
自1979年以来，魁北克毒理学中心开展了一项针对血液和尿液中多种有毒物质的实验室间比对计划。由于缺乏可靠且具有代表性的血液和尿液中有毒元素参考物质，我们启动了该计划。其主要目标是通过定期比较结果，使参与者能够提高或保持其分析工作的准确性。目前，该计划中有76个实验室登记参与一种或多种物质的检测。大多数实验室位于北美，其他一些在欧洲和南美。可供检测的物质包括血液中的铅和镉、血清中的铝以及尿液中的汞、砷、镉、氟化物和铬。样本通过汇集从接触有毒物质的工人身上采集的标本制备而成。多年来，我们一直以与目标值的偏差、结果的离散度以及在预设毒理学意义限度内的熟练度为标准，来考察参与者的表现。只要有可能，我们就会评估分析方法的影响。参与该计划所提供的反馈似乎是维持或提高分析熟练度的一个重要因素。绝大多数参与者获得的结果可靠性足以用于监测接触有毒物质的工人。
