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温哥华24至36个月大儿童的血铅水平。

Blood lead levels in children aged 24 to 36 months in Vancouver.

作者信息

Jin A, Hertzman C, Peck S H, Lockitch G

机构信息

University of British Columbia, Vancouver.

出版信息

CMAJ. 1995 Apr 1;152(7):1077-86.

Abstract

OBJECTIVES

To determine the blood lead levels in children and to identify risk factors for elevated levels.

DESIGN

Cross-sectional study.

SETTING

Vancouver.

PARTICIPANTS

Random sample of children aged 24 to 36 months, born and still resident in Vancouver. The sample was stratified proportionally by the median annual family income in the census tract where each family resided.

OUTCOME MEASURES

Blood lead levels and risk factors for elevated blood lead levels, determined from a questionnaire administered to parents.

RESULTS

Of the children in the sample, 42% (178/422) were ineligible or could not be located. Of the remaining children, 73% (177/244) participated and adequate blood specimens were obtained from 172. The mean blood lead level was 0.29 mumol/L (standard deviation 0.13 mumol/L). (A blood lead level of 1 mumol/L is equivalent to 20.7 micrograms/dL.) The lowest level was 0.06 mumol/L, and the highest was 0.85 mumol/L. Of children with adequate samples, 8.1% (14/172) had blood lead levels of 0.48 mumol/L or higher, and 0.6% (1/172) had a level higher than 0.72 mumol/L. The logarithms of the levels were normally distributed, with a geometric mean (GM) of 0.26 mumol/L (geometric standard deviation 1.56). Of approximately 70 possible predictors of blood lead levels analysed, those that showed a statistically significant association (p < 0.05) with increased blood lead levels were soldering performed in the home as part of an electronics hobby (GM blood lead level 0.34 mumol/L, 95% confidence interval [CI] 0.27 to 0.39 mumol/L), aboriginal heritage (GM blood lead level 0.33 mumol/L, 95% CI 0.28 to 0.39 mumol/L), dwelling built before 1921 (GM blood lead level 0.32 mumol/L, 95% CI 0.28 to 0.37 mumol/L), age of water service connection to dwelling (predicted blood lead level 0.00087 mumol/L [95% CI 0.00005 to 0.00169 mumol/L] higher per year since service connection) and decreased stature (predicted blood lead level 0.018 mumol/L [95% CI 0.0353 to 0.0015 mumol/L] higher for every standard deviation below the age-specific mean height).

CONCLUSIONS

This study found much lower blood lead levels in children than those found in previous Canadian studies. The authors believe that this result is not an artefact due to differences in population sampling or methods of collection of blood specimens. The study showed no clear risk factors for elevated blood lead levels: although a few factors had a statistically significant association with increased blood lead levels, the differences in levels were small and unimportant.

摘要

目的

测定儿童血铅水平并确定血铅水平升高的危险因素。

设计

横断面研究。

地点

温哥华。

参与者

对年龄在24至36个月、在温哥华出生且仍居住在该地的儿童进行随机抽样。样本按每个家庭所在普查区的家庭年收入中位数进行比例分层。

观察指标

通过向家长发放问卷确定血铅水平及血铅水平升高的危险因素。

结果

样本中的儿童有42%(178/422)不符合条件或无法找到。在其余儿童中,73%(177/244)参与了研究,且从172名儿童中获取了足够的血标本。血铅水平均值为0.29μmol/L(标准差0.13μmol/L)。(血铅水平1μmol/L相当于20.7μg/dL。)最低水平为0.06μmol/L,最高水平为0.85μmol/L。在有足够样本的儿童中,8.1%(14/172)的血铅水平达到或高于0.48μmol/L,0.6%(1/172)的血铅水平高于0.72μmol/L。血铅水平的对数呈正态分布,几何均值(GM)为0.26μmol/L(几何标准差1.56)。在分析的约70个可能的血铅水平预测因素中,与血铅水平升高呈统计学显著关联(p<0.05)的因素有:作为电子爱好的一部分在家中进行焊接(血铅水平GM为0.34μmol/L,95%置信区间[CI]为0.27至0.39μmol/L)、原住民血统(血铅水平GM为0.33μmol/L,95%CI为0.28至0.39μmol/L)、1921年前建造的住宅(血铅水平GM为0.32μmol/L,95%CI为0.28至0.37μmol/L)、住宅供水连接的使用年限(自连接以来每年预测血铅水平升高0.00087μmol/L[95%CI为0.00005至0.00169μmol/L])以及身高降低(低于特定年龄平均身高每一个标准差,预测血铅水平升高0.018μmol/L[95%CI为0.0353至0.0015μmol/L])。

结论

本研究发现儿童血铅水平远低于加拿大以往研究中的水平。作者认为这一结果并非因人群抽样或血标本采集方法的差异所致。该研究未显示出血铅水平升高的明确危险因素:尽管有几个因素与血铅水平升高呈统计学显著关联,但水平差异较小且不重要。

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Blood lead and associated risk factors in Ontario children.安大略省儿童的血铅水平及相关风险因素。
Sci Total Environ. 1988 Jun 1;71(3):477-83. doi: 10.1016/0048-9697(88)90221-5.

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